ELVN / Enliven Therapeutics, Inc. - SEC फाइलिंग, वार्षिक रिपोर्ट, प्रॉक्सी स्टेटमेंट

एनलिवेन थेरेप्यूटिक्स, इंक.
US ˙ NasdaqGS ˙ US29337E1029

मूलभूत आँकड़े
CIK 1672619
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Enliven Therapeutics, Inc.
SEC Filings (Chronological Order)
यह पृष्ठ SEC फाइलिंग की एक पूरी, कालानुक्रमिक सूची प्रदान करता है, ओनरशिप फाइलिंग को छोड़कर, जो हम अन्यत्र प्रदान करते हैं।
August 13, 2025 EX-FILING FEES

Filing Fee Table

Calculation of Filing Fee Tables S-3 Enliven Therapeutics, Inc. Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward

August 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAPEUTICS, INC.

August 13, 2025 8-K

FORM 8-K Item 2.02 Results of Operations and Financial Condition. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2025 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commiss

August 13, 2025 EX-99.1

Enliven Therapeutics Reports Second Quarter Financial Results and Provides a Business Update Announced positive data from the Phase 1 clinical trial of ELVN-001 in CML, reporting a cumulative MMR rate of 47% with 32% of patients achieving MMR by 24 w

Exhibit 99.1 Enliven Therapeutics Reports Second Quarter Financial Results and Provides a Business Update Announced positive data from the Phase 1 clinical trial of ELVN-001 in CML, reporting a cumulative MMR rate of 47% with 32% of patients achieving MMR by 24 weeks and demonstrating a favorable safety and tolerability profile across all dose levels Strong balance sheet with $491 million in cash,

August 13, 2025 S-3ASR

As filed with the Securities and Exchange Commission on August 13, 2025

S-3ASR Table of Contents As filed with the Securities and Exchange Commission on August 13, 2025 Registration No.

August 13, 2025 EX-4.3

Form of Indenture

EX-4.3 Exhibit 4.3 ENLIVEN THERAPEUTICS, INC. INDENTURE Dated as of , 20 [    ] Trustee TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1 Definitions 1 Section 1.2 Other Definitions 4 Section 1.3 Incorporation by Reference of Trust Indenture Act 4 Section 1.4 Rules of Construction 5 ARTICLE II THE SECURITIES 5 Section 2.1 Issuable in Series 5 Section 2.2 Est

June 25, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 24, 2025 Enliven Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 24, 2025 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissio

June 16, 2025 424B5

8,394,737 Shares of Common Stock Pre-Funded Warrants to Purchase 1,780,263 Shares of Common Stock

424B5 Table of Contents As Filed Pursuant to Rule 424(b)(5) Registration No. 333-272909 PROSPECTUS SUPPLEMENT (To Prospectus dated July 6, 2023) 8,394,737 Shares of Common Stock Pre-Funded Warrants to Purchase 1,780,263 Shares of Common Stock We are offering 8,394,737 shares of our common stock and, in lieu of common stock to investors that so choose, pre-funded warrants to purchase up to 1,780,26

June 16, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2025 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissio

June 16, 2025 EX-1.1

Underwriting Agreement, dated as of June 13, 2025, among Enliven Therapeutics, Inc. and the Representatives.

Exhibit 1.1 8,394,737 Shares of Common Stock And Pre-Funded Warrants to Purchase 1,780,263 Shares of Common Stock Enliven Therapeutics, Inc. UNDERWRITING AGREEMENT June 13, 2025 JEFFERIES LLC GOLDMAN SACHS & CO. LLC TD SECURITIES (USA) LLC MIZUHO SECURITIES USA LLC As Representatives of the several Underwriters c/o JEFFERIES LLC 520 Madison Avenue New York, New York 10022 c/o GOLDMAN SACHS & CO. L

June 16, 2025 EX-99.1

Enliven Therapeutics Announces Pricing of Public Offering of Common Stock and

Exhibit 99.1 Enliven Therapeutics Announces Pricing of Public Offering of Common Stock and Pre-Funded Warrants June 13, 2025 BOULDER, COLO., Jun. 13, 2025 (PRNEWSWIRE) – Enliven Therapeutics, Inc. (Enliven or the Company) (Nasdaq: ELVN), a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule therapeutics, today announced that it has priced its previou

June 16, 2025 EX-4.1

Form of Pre-Funded Warrant

Exhibit 4.1 FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK Number of Shares: [     ] (subject to adjustment) Warrant No.  Original Issue Date: [  ], 2025 ENLIVEN THERAPEUTICS, INC. Enliven Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [ ] or its registered as

June 13, 2025 424B5

$200,000,000 Shares of Common Stock Pre-Funded Warrants to Purchase Shares of Common Stock

424B5 Table of Contents As Filed Pursuant to Rule 424(b)5 Registration No. 333-272909 The information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are part of an effective registration statement relating to these securities filed with the Securities and Exchange Commission under the Securities A

June 13, 2025 EX-99.1

Enliven Therapeutics Announces Updated Positive Data from Phase 1 Clinical Trial of ELVN-001 in CML at EHA 2025 Congress Reported cumulative MMR rate of 47% (25 of 53) by 24 weeks with 32% (13 of 41) of patients achieving MMR by 24 weeks, which conti

EX-99.1 Exhibit 99.1 Enliven Therapeutics Announces Updated Positive Data from Phase 1 Clinical Trial of ELVN-001 in CML at EHA 2025 Congress Reported cumulative MMR rate of 47% (25 of 53) by 24 weeks with 32% (13 of 41) of patients achieving MMR by 24 weeks, which continues to compare favorably to precedent Phase 1 trials of approved BCR::ABL1 TKIs ELVN-001 continues to demonstrate a favorable sa

June 13, 2025 S-3MEF

As filed with the Securities and Exchange Commission on June 13, 2025

S-3MEF As filed with the Securities and Exchange Commission on June 13, 2025 Registration No.

June 13, 2025 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107.1 Calculation of Filing Fee Tables FORM S-3 (Form Type) ENLIVEN THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Fees to Be Pai

June 13, 2025 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2025 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissio

May 14, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2025 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission

May 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAPEUTICS, INC.

May 14, 2025 EX-99.1

Enliven Therapeutics Reports First Quarter Financial Results and Provides a Business Update Updated data from the Phase 1 ENABLE clinical trial of ELVN-001 in CML to be presented at the EHA 2025 Congress in June EHA abstract reported cumulative MMR r

Exhibit 99.1 Enliven Therapeutics Reports First Quarter Financial Results and Provides a Business Update Updated data from the Phase 1 ENABLE clinical trial of ELVN-001 in CML to be presented at the EHA 2025 Congress in June EHA abstract reported cumulative MMR rate of 44% (16 of 36) by 24 weeks with 26% (7 of 27) of patients achieving MMR by 24 weeks, and ELVN-001 remains well-tolerated with 74 p

April 28, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant  ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ De

April 28, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Pro

March 13, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAP

March 13, 2025 S-8

As filed with the Securities and Exchange Commission on March 13, 2025

As filed with the Securities and Exchange Commission on March 13, 2025 Registration No.

March 13, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2025 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissi

March 13, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Form S-8 (Form Type) Enliven Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity  Common Stock, par value

March 13, 2025 EX-19.1

Insider Trading Policy

Exhibit 19.1 ENLIVEN THERAPEUTICS, INC. INSIDER TRADING POLICY (As amended on February 6, 2025) A. POLICY OVERVIEW Enliven Therapeutics, Inc. (together with any subsidiaries, collectively “Enliven”) has adopted this Insider Trading Policy (the “Policy”) to help you comply with the federal and state securities laws and regulations that govern trading in securities and to help Enliven minimize its o

March 13, 2025 EX-21.1

List of Subsidiaries of Enliven Therapeutics, Inc.

Exhibit 21.1 LIST OF SUBSIDIARIES OF ENLIVEN THERAPEUTICS, INC. Name Jurisdiction of Incorporation Enliven Inc. Delaware IMARA Security Corporation Massachusetts

March 13, 2025 EX-10.16

Outside Director Compensation Policy, as amended January 1, 2025

Exhibit 10.16 ENLIVEN THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY Adopted and approved February 23, 2023 As amended January 1, 2025 (the “Effective Date”) Enliven Therapeutics, Inc. (the “Company”) believes that providing cash and equity compensation to members of its Board of Directors (the “Board,” and members of the Board, the “Directors”) represents an effective tool to attract, re

March 13, 2025 EX-99.1

Enliven Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides a Business Update Updated Phase 1 data for ELVN-001 expected mid-2025 as positive enrollment momentum continues Expected monotherapy and combination data fr

Exhibit 99.1 Enliven Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides a Business Update Updated Phase 1 data for ELVN-001 expected mid-2025 as positive enrollment momentum continues Expected monotherapy and combination data from the ELVN-002 Phase 1 trials in second half of 2025 Strong balance sheet with $313 million in cash, cash equivalents and marketable sec

November 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 tm2427451d15sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* ENLIVEN THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Stat

November 14, 2024 EX-99.1

Exhibit 1: Joint Filing Agreement

EX-99.1 2 tm2427451d15ex1.htm EXHIBIT 1 EXHIBIT 1 AGREEMENT This Joint Filing Agreement, dated as of November 14, 2024, is by and among RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (the foregoing are collectively referred to herein as the “Filers”). Each of the Filers may be required to file with the United States Securities and Exchange Commissi

November 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / CITADEL ADVISORS LLC - SC 13G/A Passive Investment

SC 13G/A 1 tm2427061d10sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 2)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (the “Share

November 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / COMMODORE CAPITAL LP Passive Investment

SC 13G/A 1 formsc13ga.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appr

November 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / Venrock Healthcare Capital Partners III, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 tm2428137d9sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this State

November 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / Fairmount Funds Management LLC - SC 13G/A Passive Investment

SC 13G/A 1 tm2427721d4sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, Par Value $0.001 (Title of Class of Securities) 29337E102 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of This Statement) Check

November 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2024 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commi

November 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAPEUTICS, INC.

November 13, 2024 EX-99.1

Enliven Therapeutics Reports Third Quarter Financial Results and Provides a Business Update Announced positive data from the Phase 1 clinical trial of ELVN-001 in CML, reporting a cumulative MMR rate of 44% (8/18) by 24 weeks and showing that ELVN-00

Exhibit 99.1 Enliven Therapeutics Reports Third Quarter Financial Results and Provides a Business Update Announced positive data from the Phase 1 clinical trial of ELVN-001 in CML, reporting a cumulative MMR rate of 44% (8/18) by 24 weeks and showing that ELVN-001 remains well-tolerated with no dose reductions Continued to progress ELVN-002 with a focus on recently initiated combination clinical t

November 13, 2024 SC 13G

ELVN / Enliven Therapeutics, Inc. / Polar Capital Holdings Plc Passive Investment

SC 13G 1 polar-elvn093024.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* ENLIVEN THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 29337E102 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the a

August 13, 2024 EX-99.1

Enliven Therapeutics Reports Second Quarter Financial Results and Provides a Business Update Dosed the first patient in the Phase 1b arm of the clinical trial evaluating ELVN-001 in patients with CML that is relapsed, refractory or intolerant to avai

Exhibit 99.1 Enliven Therapeutics Reports Second Quarter Financial Results and Provides a Business Update Dosed the first patient in the Phase 1b arm of the clinical trial evaluating ELVN-001 in patients with CML that is relapsed, refractory or intolerant to available TKIs Dosed the first patient in the Phase 1a clinical trial evaluating ELVN-002 in combination with trastuzumab +/- chemotherapeuti

August 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2024 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commiss

August 13, 2024 EX-3.1

The Company's Restated Certificate of Incorporation, as amended June 18, 2024

Exhibit 3.1 RESTATED CERTIFICATE OF INCORPORATION OF IMARA INC. IMARA Inc., a corporation organized and existing under the General Corporation Law of the State of Delaware, does hereby certify that the name of the corporation is IMARA Inc. and the original certificate of incorporation of the corporation was filed with the Secretary of State of the State of Delaware on January 26, 2016. This Restat

August 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAPEUTICS, INC.

July 29, 2024 SC 13D/A

ELVN / Enliven Therapeutics, Inc. / 5AM Ventures VI, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2420416d1sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 5)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) 5AM Venture Management, LLC Attn: Paul A. Stone, Chief Legal Officer 4

June 20, 2024 S-8

As filed with the Securities and Exchange Commission on June 18, 2024

S-8 As filed with the Securities and Exchange Commission on June 18, 2024 Registration No.

June 20, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Form S-8 (Form Type) Enliven Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee  Calculation  Rule Amount Registered (1) Proposed  Maximum  Offering Price Per Unit  Maximum   Aggregate  Offering Price Fee Rate Amount of Registration  Fee Equity Common Stock, pa

June 18, 2024 EX-10.1

Amended and Restated 2020 Equity Incentive Plan

Exhibit 10.1 ENLIVEN THERAPEUTICS, INC. AMENDED AND RESTATED 2020 EQUITY INCENTIVE PLAN 1. Purpose. The purpose of this Amended and Restated 2020 Equity Incentive Plan (the “Plan”) of Enliven Therapeutics, Inc., a Delaware corporation (the “Company”), is to advance the interests of the Company’s stockholders by enhancing the Company’s ability to attract, retain and motivate persons who are expecte

June 18, 2024 EX-3.1

Certificate of Amendment to the Company’s Restated Certificate of Incorporation, dated June 18, 2024

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE RESTATED CERTIFICATE OF INCORPORATION OF ENLIVEN THERAPEUTICS, INC. (Pursuant to Section 242 of the General Corporation Law of the State of Delaware) Enliven Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), DOES HEREBY CERTIFY: 1. The name of the Corporation is Enliven Therapeutics, Inc

June 18, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2024 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissio

May 29, 2024 8-K/A

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (AMENDMENT NO. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2024 (April 8, 2024) Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisd

May 20, 2024 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 ss3408593ex9901.htm JOINT FILING AGREEMENT Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that Amendment No. 2 to the Statement on Schedule 13D, dated May 16, 2024, with respect to the common stock of Enliven Therapeutics, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as a

May 20, 2024 SC 13D/A

ELVN / Enliven Therapeutics, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 2 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2) Enliven Therapeutics, Inc. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 29337E102 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP VII LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601 Lexington Avenue, 54th Floor New York, NY 10022

May 14, 2024 EX-99.1

Enliven Therapeutics Reports First Quarter Financial Results and Provides a Business Update Announced positive proof of concept data from Phase 1 clinical trial of ELVN-001 in CML, achieving an initial cumulative MMR rate of 44% (7/16) by 12 weeks in

Enliven Therapeutics Reports First Quarter Financial Results and Provides a Business Update Announced positive proof of concept data from Phase 1 clinical trial of ELVN-001 in CML, achieving an initial cumulative MMR rate of 44% (7/16) by 12 weeks in response-evaluable patients Strong balance sheet with $321 million in cash, cash equivalents and marketable securities, which is expected to provide cash runway into late 2026 BOULDER, Colo.

May 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAPEUTICS, INC.

May 14, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2024 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission

April 30, 2024 424B3

Enliven Therapeutics, Inc. 6,428,649 Shares of Common Stock

Table of Contents Filed pursuant to Rule 424(b)(3) Registration No. 333-278801 PROSPECTUS Enliven Therapeutics, Inc. 6,428,649 Shares of Common Stock This prospectus relates to the offer and resale from time to time of up to 6,428,649 shares (the “Shares”) of our common stock, par value $0.001 per share, by the selling stockholders identified in this prospectus, including their transferees, pledge

April 26, 2024 CORRESP

Enliven Therapeutics, Inc. 6200 Lookout Road Boulder, Colorado 80301 April 26, 2024

Enliven Therapeutics, Inc. 6200 Lookout Road Boulder, Colorado 80301 April 26, 2024 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Enliven Therapeutics, Inc. Registration Statement on Form S-3 Filed April 18, 2024 File No. 333-278801 Acceleration Request  Requested Date:  April 30, 2024  Requested Time: 4:00 p.m. Eastern T

April 26, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defi

April 26, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

April 18, 2024 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107 CALCULATION OF FILING FEE TABLES Form S-3 (Form Type) Enliven Therapeutics, Inc.

April 18, 2024 S-3

As filed with the Securities and Exchange Commission on April 18, 2024

Table of Contents As filed with the Securities and Exchange Commission on April 18, 2024 Registration No.

April 18, 2024 CORRESP

April 18, 2024

Wilson Sonsini Goodrich & Rosati Professional Corporation 650 Page Mill Road Palo Alto, California 94304-1050 O: 650.

April 15, 2024 SC 13D/A

ELVN / Enliven Therapeutics, Inc. / 5AM Ventures VI, L.P. - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 4)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) 5AM Venture Management, LLC Attn: Paul A. Stone, Chief Legal Officer 4 Embarcadero Center, Suite 3110 San Francis

April 15, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defi

April 11, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 11, 2024 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissi

April 11, 2024 EX-99.1

Enliven Therapeutics Announces Positive Proof of Concept Data from Phase 1 Clinical Trial of ELVN-001 in Chronic Myeloid Leukemia Achieved initial cumulative MMR rate of 44% (7/16) by 12 weeks in response-evaluable patients, which compares favorably

Exhibit 99.1 Enliven Therapeutics Announces Positive Proof of Concept Data from Phase 1 Clinical Trial of ELVN-001 in Chronic Myeloid Leukemia Achieved initial cumulative MMR rate of 44% (7/16) by 12 weeks in response-evaluable patients, which compares favorably to precedent Phase 1 trials of approved BCR::ABL1 TKIs Achieved initial cumulative MMR rate of 44% (4/9) by 12 weeks in response-evaluabl

April 9, 2024 EX-99.1

Enliven Therapeutics Appoints Dr. Lori Kunkel to Board of Directors

Exhibit 99.1 Enliven Therapeutics Appoints Dr. Lori Kunkel to Board of Directors BOULDER, Colo., April 09, 2024 (GLOBE NEWSWIRE) – Enliven Therapeutics, Inc. (Enliven or the Company) (Nasdaq: ELVN), a clinical-stage precision oncology company focused on the discovery and development of next-generation small molecule kinase inhibitors, today announced the appointment of Lori Kunkel, MD, to its Boar

April 9, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 8, 2024 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissio

April 4, 2024 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 ss3223565ex9901.htm JOINT FILING AGREEMENT Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that Amendment No. 1 to the Statement on Schedule 13D, dated April 2, 2024, with respect to the common stock of Enliven Therapeutics, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as

April 4, 2024 SC 13D/A

ELVN / Enliven Therapeutics, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 1 Activist Investment

SC 13D/A 1 ss3223565sc13da.htm AMENDMENT NO. 1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1) Enliven Therapeutics, Inc. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 29337E102 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP VII LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601

March 19, 2024 EX-99.1

Enliven Therapeutics Announces $90 Million Private Placement Financing and Provides Pipeline Updates Financing includes participation from new and existing investors Net proceeds, along with existing cash, cash equivalents and marketable securities,

Exhibit 99.1 Enliven Therapeutics Announces $90 Million Private Placement Financing and Provides Pipeline Updates Financing includes participation from new and existing investors Net proceeds, along with existing cash, cash equivalents and marketable securities, are expected to extend cash runway into late 2026 and through multiple key clinical milestones for ELVN-001 and ELVN-002 Company to host

March 19, 2024 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 19, 2024 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissi

March 19, 2024 EX-10.1

Securities Purchase Agreement, dated March 19, 2024, by and among the Company and the Purchasers named therein

Exhibit 10.1 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6). ENLIVEN THERAPEUTICS, INC. SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (the “Agreement”) is made as of March 19, 2024 (the “Effective Date”), by and among Enliven Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the purchasers whose names and

March 19, 2024 EX-4.1

Form of Pre-Funded Warrant

Exhibit 4.1 THESE SECURITIES REPRESENTED HEREBY AND THE SECURITIES ISSUABLE UPON EXERCISE OF THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE BUT HAVE BEEN OR WILL BE ISSUED IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND, ACCORDINGLY, MAY NOT BE TRANSFERRED UNLESS (i) S

March 14, 2024 S-8

As filed with the Securities and Exchange Commission on March 14, 2024

As filed with the Securities and Exchange Commission on March 14, 2024 Registration No.

March 14, 2024 EX-10.14

Joseph Lyssikatos Change in Control and Severance Agreement, as amended and restated February 29, 2024

Exhibit 10.14 AMENDED AND RESTATED CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Amended and Restated Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Joseph Lyssikatos (the “Executive”). This Agreement provides certain protections to the Executive in connection with a change in control of the Company or in connection with

March 14, 2024 EX-10.11

Sam Kintz Change in Control and Severance Agreement, as amended and restated February 29, 2024

Exhibit 10.11 AMENDED AND RESTATED CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Amended and Restated Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Samuel Kintz (the “Executive”). This Agreement provides certain protections to the Executive in connection with a change in control of the Company or in connection with the i

March 14, 2024 EX-99.1

Enliven Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides a Business Update Initial proof of concept data from Phase 1a trial evaluating ELVN-001 in adults with chronic myeloid leukemia (CML) is expected in the sec

Enliven Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides a Business Update Initial proof of concept data from Phase 1a trial evaluating ELVN-001 in adults with chronic myeloid leukemia (CML) is expected in the second quarter of 2024 IND application to evaluate ELVN-002 in combination with trastuzumab in patients with HER2+ metastatic breast cancer and colorectal cancer received U.

March 14, 2024 EX-10.12

Helen Collins Change in Control and Severance Agreement, as amended and restated February 29, 2024

Exhibit 10.12 AMENDED AND RESTATED CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Amended and Restated Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Helen Collins (the “Executive”). This Agreement provides certain protections to the Executive in connection with a change in control of the Company or in connection with the

March 14, 2024 EX-10.3

2020 Employee Stock Purchase Plan

Exhibit 10.3 ENLIVEN THERAPEUTICS, INC. 2020 EMPLOYEE STOCK PURCHASE PLAN The purpose of this 2020 Employee Stock Purchase Plan (this “Plan”) is to provide eligible employees of Enliven Therapeutics, Inc. (the “Company”) and certain of its subsidiaries with opportunities to purchase shares of the Company’s common stock, $0.001 par value per share (the “Common Stock”), commencing at such time and o

March 14, 2024 EX-10.8

Benjamin Hohl Confirmatory Employment Letter, as amended and restated February 29, 2024

Exhibit 10.8 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) Enliven Therapeutics, Inc. Confirmatory Employment Letter, As Amended and Restated Benjamin Hohl [***] [***] Dear Mr. Hohl: This Confirmatory Employment Letter, as Amended and Restated (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you. T

March 14, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAP

March 14, 2024 EX-10.9

Joseph Lyssikatos Confirmatory Employment Letter, as amended and restated February 29, 2024

Exhibit 10.9 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) Enliven Therapeutics, Inc. Confirmatory Employment Letter, As Amended and Restated Joseph Lyssikatos [***] [***] Dear Dr. Lyssikatos: This Confirmatory Employment Letter, as Amended and Restated (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”)

March 14, 2024 EX-4.2

Description of the Registrant’s Securities

Exhibit 4.2 DESCRIPTION OF CAPITAL STOCK The following description of our securities registered under Section 12 of the Exchange Act is intended as a summary only and therefore is not a complete description. This description is based upon, and is qualified by reference to, our restated certificate of incorporation, our amended and restated bylaws and applicable provisions of the Delaware General C

March 14, 2024 EX-10.16

Outside Director Compensation Policy, as amended February 13, 2024

Exhibit 10.16 ENLIVEN THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY Adopted and approved February 23, 2023 As amended February 13, 2024 (the “Effective Date”) Enliven Therapeutics, Inc. (the “Company”) believes that providing cash and equity compensation to members of its Board of Directors (the “Board,” and members of the Board, the “Directors”) represents an effective tool to attract,

March 14, 2024 EX-97.1

Compensation Recovery Policy

Exhibit 97.1 ENLIVEN THERAPEUTICS, INC. COMPENSATION RECOVERY POLICY As adopted on August 15, 2023 Enliven Therapeutics, Inc. (together with any subsidiaries, collectively the “Company”) is committed to strong corporate governance. As part of this commitment, the Company’s Compensation Committee (the “Committee”) of the board of directors (the “Board”) has adopted this clawback policy called the C

March 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2024 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissi

March 14, 2024 EX-21.1

List of Subsidiaries of Enliven Therapeutics, Inc.

Exhibit 21.1 LIST OF SUBSIDIARIES OF ENLIVEN THERAPEUTICS, INC. Name Jurisdiction of Incorporation Enliven Inc. Delaware IMARA Security Corporation Massachusetts

March 14, 2024 EX-10.13

Benjamin Hohl Change in Control and Severance Agreement, as amended and restated February 29, 2024

Exhibit 10.13 AMENDED AND RESTATED CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Amended and Restated Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Ben Hohl (the “Executive”). This Agreement provides certain protections to the Executive in connection with a change in control of the Company or in connection with the invol

March 14, 2024 EX-10.15

Anish Patel Change in Control and Severance Agreement, as amended and restated February 29, 2024

Exhibit 10.15 AMENDED AND RESTATED CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Amended and Restated Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Anish Patel (the “Executive”). This Agreement provides certain protections to the Executive in connection with a change in control of the Company or in connection with the in

March 14, 2024 EX-10.6

Sam Kintz Confirmatory Employment Letter, as amended and restated February 29, 2024

Exhibit 10.6 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) Enliven Therapeutics, Inc. Confirmatory Employment Letter, As Amended and Restated Samuel Kintz [***] [***] Dear Mr. Kintz: This Confirmatory Employment Letter, as Amended and Restated (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you. T

March 14, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Form S-8 (Form Type) Enliven Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security  Type  Security  Class  Title  Fee  Calculation  Rule  Amount  Registered (1)  Proposed  Maximum  Offering  Price  Per Unit  Maximum  Aggregate  Offering Price  Fee  Rate  Amount of  Registration  Fee  Equity  C

March 14, 2024 EX-10.10

Anish Patel Confirmatory Employment Letter, as amended and restated February 29, 2024

Exhibit 10.10 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) Enliven Therapeutics, Inc. Confirmatory Employment Letter, As Amended and Restated Anish Patel [***] [***] Dear Dr. Patel: This Confirmatory Employment Letter, as Amended and Restated (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you. T

March 14, 2024 EX-10.7

Helen Collins Confirmatory Employment Letter, as amended and restated February 29, 2024

Exhibit 10.7 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) Enliven Therapeutics, Inc. Confirmatory Employment Letter, As Amended and Restated Helen Collins [***] [***] Dear Dr. Collins: This Confirmatory Employment Letter, as Amended and Restated (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you

February 16, 2024 SC 13D/A

ELVN / Enliven Therapeutics, Inc. / 5AM Ventures VI, L.P. - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) 5AM Venture Management, LLC Attn: Paul A. Stone, Chief Legal Officer 501 2nd Street, Suite 350 San Francisco, CA

February 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / Venrock Healthcare Capital Partners III, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 tm246235d7sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Stateme

February 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / COMMODORE CAPITAL LP Passive Investment

SC 13G/A 1 formsc13ga.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appro

February 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / PFIZER INC - SC 13G/A ENLIVEN THERAPEUTICS Passive Investment

SC 13G/A 1 enlivenschedule13gaexitfil.htm SC 13G/A ENLIVEN THERAPEUTICS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1 – Exit Filing)1 ENLIVEN THERAPEUTICS, INC. (formerly, IMARA Inc.) (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 29337E102 (CUSIP Number) December 31, 2

February 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / CITADEL ADVISORS LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 1)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (the “Shares”) (Title of Class of Securities) 29337E10

February 14, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / Fairmount Funds Management LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, Par Value $0.001 (Title of Class of Securities) 29337E102 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule p

February 7, 2024 SC 13G/A

ELVN / Enliven Therapeutics, Inc. / BML Investment Partners, L.P. Passive Investment

SC 13G/A 1 elvn13g020724.htm SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (AMENDMENT NO. 3 )* Enliven Therapeutics, Inc. (Name of Issuer) Common stock, par value $0.001 per share (Title of Class of Securities) 29337E

February 2, 2024 SC 13D/A

ELVN / Enliven Therapeutics, Inc. / 5AM Ventures VI, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm245036d1sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) 5AM Venture Management, LLC Attn: Paul A. Stone, Chief Legal Officer 501

November 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 09, 2023 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commi

November 9, 2023 EX-99.1

Enliven Therapeutics Reports Third Quarter 2023 Financial Results and Provides a Business Update Company on track to deliver initial proof of concept data for ELVN-001 and ELVN-002 in 2024 Strong balance sheet, closing the quarter with $263 million i

Enliven Therapeutics Reports Third Quarter 2023 Financial Results and Provides a Business Update Company on track to deliver initial proof of concept data for ELVN-001 and ELVN-002 in 2024 Strong balance sheet, closing the quarter with $263 million in cash, cash equivalents and marketable securities, which is expected to provide cash runway into early 2026 BOULDER, Colo.

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAPEUTICS, INC.

August 28, 2023 SC 13D/A

ELVN / Enliven Therapeutics Inc / 5AM Ventures VI, L.P. - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) 5AM Venture Management, LLC Attn: Rebecca Lucia, Chief Financial Officer 501 2nd Street, Suite 350 San Francisco,

August 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2023 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commiss

August 10, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAPEUTICS, INC.

August 10, 2023 EX-99.1

Enliven Therapeutics Reports Second Quarter 2023 Financial Results and Highlights Recent Company Progress Continued progress of parallel lead programs, ELVN-001 and ELVN-002, through dose escalation in Phase 1 trials, with initial proof of concept da

Enliven Therapeutics Reports Second Quarter 2023 Financial Results and Highlights Recent Company Progress Continued progress of parallel lead programs, ELVN-001 and ELVN-002, through dose escalation in Phase 1 trials, with initial proof of concept data for both programs expected in 2024 Strong balance sheet, closing the quarter with $278 million in cash, cash equivalents and marketable securities BOULDER, Colo.

July 6, 2023 424B5

Up to $200,000,000 Common Stock

424B5 Table of Contents As Filed Pursuant to Rule 424(b)5 Registration No. 333-272909 (To Prospectus dated July 6, 2023) PROSPECTUS SUPPLEMENT Up to $200,000,000 Common Stock We have entered into an Open Market Sale AgreementSM (the “Sales Agreement”) with Jefferies LLC (“Jefferies”) relating to the sale of shares of our common stock, par value $0.001 per share, offered by this prospectus suppleme

June 29, 2023 CORRESP

Enliven Therapeutics, Inc. 6200 Lookout Road Boulder, Colorado 80301 June 29, 2023

Enliven Therapeutics, Inc. 6200 Lookout Road Boulder, Colorado 80301 June 29, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Enliven Therapeutics, Inc. Registration Statement on Form S-3 Filed June 23, 2023 File No. 333-272909 Acceleration Request Requested Date: July 3, 2023 Requested Time: 4:00 p.m. Eastern Time, or

June 26, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 23, 2023 Enliven Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 23, 2023 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissio

June 26, 2023 EX-1.1

Open Market Sale AgreementSM, dated June 23, 2023, by and between Enliven Therapeutics, Inc. and Jefferies LLC

Exhibit 1.1 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) OPEN MARKET SALE AGREEMENTSM June 23, 2023 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Enliven Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time t

June 23, 2023 EX-99.1

FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA INDEX TO FINANCIAL STATEMENTS ENLIVEN THERAPEUTICS, INC.

Exhibit 99.1 FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA INDEX TO FINANCIAL STATEMENTS ENLIVEN THERAPEUTICS, INC. Page Report of Independent Registered Public Accounting Firm F-2 Financials Statements as of December 31, 2022 and 2021 and for the years ended December 31, 2022 and 2021 F-3 Balance Sheets F-3 Statements of Operations and Comprehensive Loss F-4 Statements of Convertible Preferred Stoc

June 23, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-3 (Form Type) ENLIVEN THERAPEUTICS, INC.

June 23, 2023 EX-99.2

UNAUDITED PRO FORMA COMBINED FINANCIAL INFORMATION

EX-99.2 Exhibit 99.2 UNAUDITED PRO FORMA COMBINED FINANCIAL INFORMATION Explanatory Note On October 13, 2022, Imara Inc. (“Imara” or the “Company”), Enliven Therapeutics, Inc. (“Enliven”), and a wholly owned subsidiary of Imara, Iguana Merger Sub, Inc. (“Merger Sub”) entered into an agreement and plan of merger (the “Merger Agreement”). Pursuant to the Merger Agreement, among other matters, Merger

June 23, 2023 EX-4.1

Form of Specimen Common Stock Certificate (incorporated by reference)

Exhibit 4.1 . ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# COMMON STOCK COMMON STOCK PO PAR VALUE $0.001 MR ADD ADD ADD ADD 4321A BOX DESIGNATION SAMPLE Certificate Shares 43004, 0 0 0 0 0 0 (IF Number 0 0 0 0 0 0 ANY) ZQ00000000 0 0 0 0 0 0 PROVIDENCE, ENLIVEN THERAPEUTICS, INC. 0 0 0 0 0 0 RI 0 0 0 0 0 0 INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE Mr. Alexander David Sample Mr. A

June 23, 2023 S-3

As filed with the Securities and Exchange Commission on June 23, 2023

S-3 Table of Contents As filed with the Securities and Exchange Commission on June 23, 2023 Registration No.

June 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 23, 2023 Enliven Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 23, 2023 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commissio

June 23, 2023 EX-1.2

Open Market Sale AgreementSM, dated June 23, 2023, by and between Enliven Therapeutics, Inc. and Jefferies LLC

Exhibit 1.2 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) OPEN MARKET SALE AGREEMENTSM June 23, 2023 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Enliven Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time t

June 23, 2023 EX-4.3

Form of Indenture

Exhibit 4.3 ENLIVEN THERAPEUTICS, INC. INDENTURE Dated as of , 20 [ ] Trustee TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1 Definitions 1 Section 1.2 Other Definitions 4 Section 1.3 Incorporation by Reference of Trust Indenture Act 4 Section 1.4 Rules of Construction 4 ARTICLE II THE SECURITIES 5 Section 2.1 Issuable in Series 5 Section 2.2 Establishment

May 11, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 ENLIVEN THERAPEUTICS, INC.

May 11, 2023 EX-10

Anish Patel Change in Control and Severance Agreement, dated February 23, 2023

Exhibit 10.15 ENLIVEN THERAPEUTICS, Inc. CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Anish Patel (the “Executive”), effective as of February 23, 2023 (the “Effective Date”). This Agreement provides certain protections to the Executive in connection with a change in control

May 11, 2023 EX-3

The Company's Restated Certificate of Incorporation, as amended February 23, 2023

Exhibit 3.1 RESTATED CERTIFICATE OF INCORPORATION OF IMARA INC. IMARA Inc., a corporation organized and existing under the General Corporation Law of the State of Delaware, does hereby certify that the name of the corporation is IMARA Inc. and the original certificate of incorporation of the corporation was filed with the Secretary of State of the State of Delaware on January 26, 2016. This Restat

May 11, 2023 EX-10

Joseph Lyssikatos Confirmatory Employment Letter, dated February 23, 2023

Exhibit 10.9 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) Enliven Therapeutics, Inc. Confirmatory Employment Letter February 23, 2023 Joseph Lyssikatos [***] [***] Dear Dr. Lyssikatos: This letter agreement (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you. This Agreement is effective as of the

May 11, 2023 EX-10

Anish Patel Confirmatory Employment Letter, dated February 23, 2023

Exhibit 10.10 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) Enliven Therapeutics, Inc. Confirmatory Employment Letter February 23, 2023 Anish Patel [***] [***] Dear Dr. Patel: This letter agreement (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you. This Agreement is effective as of the date sign

May 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2023 Enliven Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2023 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission

May 11, 2023 EX-10

Joseph Lyssikatos Change in Control and Severance Agreement, dated February 23, 2023

Exhibit 10.14 ENLIVEN THERAPEUTICS, Inc. CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Joseph Lyssikatos (the “Executive”), effective as of February 23, 2023 (the “Effective Date”). This Agreement provides certain protections to the Executive in connection with a change in co

May 11, 2023 EX-99.1

Enliven Therapeutics Highlights Business Achievements and Reports First Quarter 2023 Financial Results Successfully completed merger with Imara Inc., trading under the new ticker symbol on Nasdaq, “ELVN” Dosed first patient in Phase 1 study of ELVN-0

Exhibit 99.1 Enliven Therapeutics Highlights Business Achievements and Reports First Quarter 2023 Financial Results Successfully completed merger with Imara Inc., trading under the new ticker symbol on Nasdaq, “ELVN” Dosed first patient in Phase 1 study of ELVN-002 in patients with HER2-altered non-small cell lung cancer (NSCLC) and other solid tumors Enrollment progressing in Phase 1 trial with E

April 28, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

April 28, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

DEF 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 27, 2023 SC 13G

ELVN / Enliven Therapeutics Inc / Fairmount Funds Management LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.)* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, Par Value $0.001 (Title of Class of Securities) 29337E102 (CUSIP Number) April 18, 2023 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursua

April 24, 2023 SC 13G

ELVN / Enliven Therapeutics Inc / COMMODORE CAPITAL LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

April 24, 2023 EX-1

Joint Filing Agreement dated as of April 24, 2023, by and between Commodore Capital LP and Commodore Capital Master LP (incorporated by reference to Exhibit 1 to the Schedule 13G filed with the Securities and Exchange Commission on April 24, 2023).

Exhibit 1 JOINT FILING AGREEMENT The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned, and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements.

March 21, 2023 EX-99.1

MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

EX-99.1 Exhibit 99.1 MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS On February 23, 2023, Enliven Therapeutics, Inc. (formerly, Imara Inc.) (the “Company”) completed its business combination with Enliven Inc. (formerly, Enliven Therapeutics, Inc.) (“Enliven”) in accordance with the terms of the Agreement and Plan of Merger, dated as of October 13, 2022 (the “

March 21, 2023 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (AMENDMENT No. 1) CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 202

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (AMENDMENT No. 1) CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2023 (February 23, 2023) Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other

March 21, 2023 EX-99.2

FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA INDEX TO FINANCIAL STATEMENTS ENLIVEN THERAPEUTICS, INC. Page Report of Independent Registered Public Accounting Firm F-2 Financials Statements as of December 31, 2022 and 2021 and for the years ended Decem

Exhibit 99.2 FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA INDEX TO FINANCIAL STATEMENTS ENLIVEN THERAPEUTICS, INC. Page Report of Independent Registered Public Accounting Firm F-2 Financials Statements as of December 31, 2022 and 2021 and for the years ended December 31, 2022 and 2021 F-3 Balance Sheets F-3 Statements of Operations and Comprehensive Loss F-4 Statements of Convertible Preferred Stoc

March 21, 2023 EX-99.3

UNAUDITED PRO FORMA COMBINED FINANCIAL INFORMATION

EX-99.3 Exhibit 99.3 UNAUDITED PRO FORMA COMBINED FINANCIAL INFORMATION Explanatory Note On October 13, 2022, Imara Inc. (“Imara” or the “Company”), Enliven Therapeutics, Inc. (“Enliven”), and a wholly owned subsidiary of Imara, Iguana Merger Sub, Inc. (“Merger Sub”) entered into an agreement and plan of merger (the “Merger Agreement”). Pursuant to the Merger Agreement, among other matters, Merger

March 13, 2023 SC 13G

ELVN / Enliven Therapeutics Inc / Venrock Healthcare Capital Partners III, L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) March 3, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the r

March 6, 2023 SC 13D

ELVN / Enliven Therapeutics Inc / 5AM Ventures VI, L.P. - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Enliven Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 29337E102 (CUSIP Number) 5AM Venture Management, LLC Attn: Galya Blachman, Ph.D., Esq., General Counsel 501 2nd Street, Suite 350 San Franc

March 6, 2023 SC 13G

ELVN / Enliven Therapeutics Inc / CITADEL ADVISORS LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. )* Enliven Therapeutics, Inc. (Name of Issuer) Common stock, par value $0.001 per share (the “Shares”) (Title of Class of Securities) 29337E102

March 6, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 tm238639d1ex99-1.htm EXHIBIT 99.1 EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the Shares of Enliven Therapeutics, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of 193

March 1, 2023 EX-99.6

ENLIVEN THERAPEUTICS, INC. INDEX TO FINANCIAL Unaudited Interim Condensed Financial Statements: Condensed Financial Statements as of September 30, 2022 and December 31, 2021 and for the Nine Months Ended September 30, 2022 and 2021 2 Balance Sheets 2

EX-99.6 Exhibit 99.6 The references to share and per share amounts in this Exhibit 99.6 to the Company’s Current Report on Form 8-K do not reflect the Reverse Stock Split, as defined in the Company’s Current Report on Form 8-K of which this Exhibit 99.6 is a part. ENLIVEN THERAPEUTICS, INC. INDEX TO FINANCIAL STATEMENTS Unaudited Interim Condensed Financial Statements: Condensed Financial Statemen

March 1, 2023 EX-10.16

Form of Indemnification Agreement of the Company

EX-10.16 Exhibit 10.16 ENLIVEN THERAPEUTICS, INC. INDEMNIFICATION AGREEMENT This Indemnification Agreement (this “Agreement”) is dated as of [insert date], and is between Enliven Therapeutics, Inc., a Delaware corporation (the “Company”), and [insert name of indemnitee] (“Indemnitee”). RECITALS A. Indemnitee’s service to the Company substantially benefits the Company. B. Individuals are reluctant

March 1, 2023 EX-10.13

Benjamin Hohl Change in Control and Severance Agreement, dated February 23, 2023

EX-10.13 Exhibit 10.13 ENLIVEN THERAPEUTICS, INC. CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Benjamin Hohl (the “Executive”), effective as of February 23, 2023 (the “Effective Date”). This Agreement provides certain protections to the Executive in connection with a change

March 1, 2023 EX-16.1

Letter dated March 1, 2023 from Ernst & Young to the Securities and Exchange Commission

EX-16.1 Exhibit 16.1 Ernst & Young LLP 200 Clarendon Street Boston, Ma 02116 Tel: (617) 266-2000 Fax: (617) 266-5843 www.ey.com March 1, 2023 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Ladies and Gentlemen: We have read Item 4.01 of Form 8-K dated February 23, 2023, of Enliven Therapeutics, Inc. (Formerly known as IMARA, Inc.) and are in agreement with the statement

March 1, 2023 S-8

As filed with the Securities and Exchange Commission on March 1, 2023

S-8 As filed with the Securities and Exchange Commission on March 1, 2023 Registration No.

March 1, 2023 EX-99.3

ENLIVEN’S BUSINESS

EX-99.3 Exhibit 99.3 ENLIVEN’S BUSINESS References to “we,” “our,” “us”, “our company” and “Enliven” refer to Enliven Therapeutics, Inc. together with its subsidiaries (formerly, Imara Inc.). References to “Former Enliven” refer to Enliven Inc. (formerly, Enliven Therapeutics, Inc.). Capitalized terms not defined herein shall have the meaning granted to them in Enliven’s definitive proxy statement

March 1, 2023 EX-99.4

ENLIVEN MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

EX-99.4 Exhibit 99.4 ENLIVEN MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS On February 23, 2023, Enliven Therapeutics, Inc. (formerly Imara Inc.) (the “Company”) completed its business combination with Enliven Inc. (formerly Enliven Therapeutics, Inc.) (“Enliven”) in accordance with the terms of Agreement and Plan of Merger, dated as of October 13, 2022 (the

March 1, 2023 EX-10.5

Amendment to the Company’s 2020 Employee Stock Purchase Plan

EX-10.5 Exhibit 10.5 AMENDMENT NO. 1 TO ENLIVEN THERAPEUTICS, INC. 2020 EMPLOYEE STOCK PURCHASE PLAN The 2020 Employee Stock Purchase Plan (the “Plan”) of IMARA Inc. is hereby amended as follows: 1. The second sentence of the first paragraph to the Plan shall be deleted in its entirety and replaced with the following: “Subject to adjustment under Section 15 hereof, the number of shares of Common S

March 1, 2023 EX-10.9

Helen Collins Confirmatory Employment Letter, dated February 23, 2023

EX-10.9 Exhibit 10.9 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) ENLIVEN THERAPEUTICS, INC. Confirmatory Employment Letter February 23, 2023 Helen Collins [***] [***] Dear Dr. Collins: This letter agreement (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you. This Agreement is effective as of th

March 1, 2023 EX-10.8

Sam Kintz Confirmatory Employment Letter, dated February 23, 2023

EX-10.8 Exhibit 10.8 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) ENLIVEN THERAPEUTICS, INC. Confirmatory Employment Letter February 23, 2023 Samuel Kintz [***] [***] Dear Mr. Kintz: This letter agreement (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you. This Agreement is effective as of the d

March 1, 2023 EX-10.2

Amended and Restated 2020 Equity Incentive Plan

EX-10.2 Exhibit 10.2 ENLIVEN THERAPEUTICS, INC. AMENDED AND RESTATED 2020 EQUITY INCENTIVE PLAN 1. Purpose The purpose of this Amended and Restated 2020 Equity Incentive Plan (the “Plan”) of IMARA Inc., a Delaware corporation (the “Company”), is to advance the interests of the Company’s stockholders by enhancing the Company’s ability to attract, retain and motivate persons who are expected to make

March 1, 2023 EX-10.11

Sam Kintz Change in Control and Severance Agreement, dated February 23, 2023

EX-10.11 Exhibit 10.11 ENLIVEN THERAPEUTICS, INC. CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Samuel Kintz (the “Executive”), effective as of February 23, 2023 (the “Effective Date”). This Agreement provides certain protections to the Executive in connection with a change i

March 1, 2023 EX-14.1

Code of Business Conduct and Ethics

EX-14.1 Exhibit 14.1 ENLIVEN THERAPEUTICS, INC. CODE OF BUSINESS CONDUCT AND ETHICS (Adopted on February 23, 2023) A. PURPOSE This Code of Business Conduct and Ethics (this “Code”) is designed to deter wrongdoing and to promote: 1. fair and accurate financial reporting; 2. compliance with applicable laws, rules and regulations including, without limitation, full, fair, accurate, timely and underst

March 1, 2023 EX-99.1

Combined company will be focused on advancing Enliven’s clinical-stage pipeline of precision oncology programs Shares to trade on Nasdaq under the new ticker symbol “ELVN” on February 24, 2023 Combined company is expected to have cash runway into ear

Exhibit 99.1 Enliven Therapeutics Closes Merger with Imara and Private Placement of $165 Million February 23, 2023 Combined company will be focused on advancing Enliven’s clinical-stage pipeline of precision oncology programs Shares to trade on Nasdaq under the new ticker symbol “ELVN” on February 24, 2023 Combined company is expected to have cash runway into early 2026 BOULDER, Colo., Feb. 23, 20

March 1, 2023 EX-10.18

Employee Incentive Compensation Plan

EX-10.18 Exhibit 10.18 ENLIVEN THERAPEUTICS, INC. EMPLOYEE INCENTIVE COMPENSATION PLAN 1. Purposes of the Plan. The Plan is intended to increase stockholder value and the success of the Company by motivating Employees to (a) perform to the best of their abilities and (b) achieve the Company’s objectives. 2. Definitions. 2.1 “Actual Award” means as to any Performance Period, the actual award (if an

March 1, 2023 EX-99.7

SELECTED HISTORICAL AND UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

EX-99.7 Exhibit 99.7 The references to share and per share amounts in this Exhibit 99.7 to the Company’s Current Report on Form 8-K do not reflect the Reverse Stock Split. Capitalized terms not defined herein shall have the meaning granted to them in the Company’s definitive proxy statement/prospectus filed with the Securities and Exchange Commission on January 23, 2023 (the “definitive proxy stat

March 1, 2023 EX-10.14

Outside Director Compensation Policy

EX-10.14 Exhibit 10.14 ENLIVEN THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY Adopted and approved February 23, 2023 (the “Effective Date”) Enliven Therapeutics, Inc. (the “Company”) believes that providing cash and equity compensation to members of its Board of Directors (the “Board,” and members of the Board, the “Directors”) represents an effective tool to attract, retain and reward Di

March 1, 2023 EX-10.10

Benjamin Hohl Confirmatory Employment Letter, dated February 23, 2023

EX-10.10 Exhibit 10.10 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) ENLIVEN THERAPEUTICS, INC. Confirmatory Employment Letter February 23, 2023 Benjamin Hohl [***] [***] Dear Mr. Hohl: This letter agreement (the “Agreement”) is entered into between Enliven Therapeutics, Inc. (the “Company” or “we”) and you. This Agreement is effective as of the

March 1, 2023 EX-3.2

Certificate of Amendment to the Company’s Restated Certificate of Incorporation, dated February 23, 2023

EX-3.2 Exhibit 3.2 CERTIFICATE OF AMENDMENT TO THE RESTATED CERTIFICATE OF INCORPORATION OF IMARA INC. (Pursuant to Section 242 of the General Corporation Law of the State of Delaware) Imara Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), DOES HEREBY CERTIFY

March 1, 2023 EX-3.1

Certificate of Amendment to the Company’s Restated Certificate of Incorporation, dated February 23, 2023

EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF RESTATED CERTIFICATE OF INCORPORATION OF IMARA INC. Imara Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), does hereby certify as follows: 1. The name of the Corporation is Imara Inc. 2. Article FOURTH of the Res

March 1, 2023 EX-99.2

RISK FACTORS

EX-99.2 Exhibit 99.2 RISK FACTORS You should carefully consider the risks described below. The occurrence of any of the following risks could have a material adverse effect on our business, financial condition, results of operations and future growth prospects or cause our actual results to differ materially from those contained in forward-looking statements we have made or may make from time to t

March 1, 2023 EX-10.1

Contingent Value Rights Agreement between the Company and Rights Agent

EX-10.1 Exhibit 10.1 [***] Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(a)(6) EXHIBIT C FORM OF CONTINGENT VALUE RIGHTS AGREEMENT BETWEEN IMARA INC. and COMPUTERSHARE INC. AND COMPUTERSHARE TRUST COMPANY, N.A., COLLECTIVELY, AS RIGHTS AGENT Dated as of February 23, 2023 FORM OF CONTINGENT VALUE RIGHTS AGREEMENT THIS CONTINGENT VALUE RIGHTS AGREEMENT (this

March 1, 2023 EX-10.6

Rahul Ballal Separation Agreement, dated February 23, 2023

EX-10.6 Exhibit 10.6 SEPARATION AGREEMENT AND GENERAL RELEASE This Separation Agreement and General Release (the “Agreement”) is entered into by and between Imara Inc. (referred to throughout this Agreement as “Employer”) and Rahul Ballal (“Employee”). The term “Party” or “Parties” as used herein shall refer to Employer, Employee, or both, as may be appropriate. The Parties are subject to the term

March 1, 2023 EX-99.5

FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA INDEX TO FINANCIAL STATEMENTS ENLIVEN THERAPEUTICS, INC. Page Report of Independent Registered Public Accounting Firm 2 Financials Statements as of December 31, 2021 and 2020 and for the years ended Decembe

EX-99.5 25 d464771dex995.htm EX-99.5 Exhibit 99.5 The references to share and per share amounts in this Exhibit 99.5 to the Company’s Current Report on Form 8-K do not reflect the Reverse Stock Split, as defined in the Company’s Current Report on Form 8-K of which this Exhibit 99.5 is a part. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA INDEX TO FINANCIAL STATEMENTS ENLIVEN THERAPEUTICS, INC. Page

March 1, 2023 EX-10.7

Michael Gray Separation Agreement, dated February 23, 2023

EX-10.7 Exhibit 10.7 SEPARATION AGREEMENT AND GENERAL RELEASE This Separation Agreement and General Release (the “Agreement”) is entered into by and between Imara Inc. (referred to throughout this Agreement as “Employer”) and Michael Gray (“Employee”). The term “Party” or “Parties” as used herein shall refer to Employer, Employee, or both, as may be appropriate. The Parties are subject to the term

March 1, 2023 EX-10.12

Helen Collins Change in Control and Severance Agreement, dated February 23, 2023

EX-10.12 Exhibit 10.12 ENLIVEN THERAPEUTICS, INC. CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Change in Control and Severance Agreement (the “Agreement”) is made between Enliven Therapeutics, Inc. (the “Company”) and Helen Collins (the “Executive”), effective as of February 23, 2023 (the “Effective Date”). This Agreement provides certain protections to the Executive in connection with a change

March 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 23, 2023 Enliven Therape

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 23, 2023 Enliven Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commi

March 1, 2023 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Form S-8 (Form Type) Enliven Therapeutics, Inc.

February 28, 2023 SC 13G/A

ELVN / Enliven Therapeutics Inc / COMMODORE CAPITAL LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 28, 2023 EX-99.2

LOCK-UP AGREEMENT

LOCK-UP AGREEMENT October 13, 2022 Enliven Therapeutics, Inc. Ladies and Gentlemen: The undersigned signatory of this lock-up agreement (this “Lock-Up Agreement”) understands that Imara Inc., a Delaware corporation (“Public Company”), has entered into an Agreement and Plan of Merger, dated as of October 13, 2022 (as the same may be amended from time to time, the “Merger Agreement”) with Iguana Mer

February 28, 2023 SC 13D

ELVN / Enliven Therapeutics Inc / ORBIMED ADVISORS LLC - SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 Enliven Therapeutics, Inc. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 29337E102 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP VII LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601 Lexington Avenue, 54th Floor New York, NY 10022 Telephone: (212)

February 28, 2023 EX-99.1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13D, dated February 23, 2023, with respect to the common stock of Enliven Therapeutics, Inc.

February 27, 2023 SC 13G/A

IMRA / Imara Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* ENLIVEN THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 45249V107 (CUSIP Number) February 23, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designat

February 22, 2023 EX-99.2

AMENDMENT NO. 1 IMARA INC. 2020 EMPLOYEE STOCK PURCHASE PLAN

EX-99.2 Exhibit 99.2 AMENDMENT NO. 1 TO IMARA INC. 2020 EMPLOYEE STOCK PURCHASE PLAN The 2020 Employee Stock Purchase Plan (the “Plan”) of IMARA Inc. is hereby amended as follows: 1. The second sentence of the first paragraph to the Plan shall be deleted in its entirety and replaced with the following: “Subject to adjustment under Section 15 hereof, the number of shares of Common Stock that have b

February 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 22, 2023 IMARA INC. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 22, 2023 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File Numbe

February 22, 2023 EX-99.3

IMARA ANNOUNCES STOCKHOLDER APPROVAL OF MERGER WITH ENLIVEN — Combined Company to Trade on Nasdaq Under Ticker “ELVN” — — Imara Announces 1-for-4 Reverse Stock Split of Common Stock —

EX-99.3 Exhibit 99.3 IMARA ANNOUNCES STOCKHOLDER APPROVAL OF MERGER WITH ENLIVEN — Combined Company to Trade on Nasdaq Under Ticker “ELVN” — — Imara Announces 1-for-4 Reverse Stock Split of Common Stock — BROOKLINE, Mass.—Feb. 22, 2023— Imara Inc. (Nasdaq: IMRA) today announced the results of the special meeting of its stockholders held on February 22, 2023. At the special meeting, Imara’s stockho

February 22, 2023 EX-3.1

Certificate of Amendment to the Company’s Restated Certificate of Incorporation, dated February 22, 2023

EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF RESTATED CERTIFICATE OF INCORPORATION OF IMARA INC. Imara Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), does hereby certify as follows: 1. The name of the Corporation is Imara Inc. 2. Article FOURTH of the Res

February 22, 2023 EX-99.1

IMARA INC. AMENDED AND RESTATED 2020 EQUITY INCENTIVE PLAN

EX-99.1 Exhibit 99.1 IMARA INC. AMENDED AND RESTATED 2020 EQUITY INCENTIVE PLAN 1. Purpose The purpose of this Amended and Restated 2020 Equity Incentive Plan (the “Plan”) of IMARA Inc., a Delaware corporation (the “Company”), is to advance the interests of the Company’s stockholders by enhancing the Company’s ability to attract, retain and motivate persons who are expected to make important contr

February 22, 2023 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 22, 2023 IMARA INC. (Exa

425 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 22, 2023 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File N

February 21, 2023 SC 13G/A

IMRA / Imara Inc / COMMODORE CAPITAL LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2023 SC 13G/A

IMRA / Imara Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 tm236221d30sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* IMARA, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 45249V107 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the

February 14, 2023 SC 13G/A

IMRA / Imara Inc / COMMODORE CAPITAL LP Passive Investment

SC 13G/A 1 formsc13ga.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Imara Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 45249V107 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to de

February 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2023 IMARA INC. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2023 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File Numbe

February 13, 2023 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2023 IMARA INC. (Exa

425 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2023 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File N

February 10, 2023 EX-10.24

Letter Agreement, dated as of January 27, 2023, by and among the Registrant, Rahul Ballal, Michael Gray and Enliven Therapeutics, Inc.

Exhibit 10.24 January 27, 2023 Enliven Therapeutics, Inc. 6200 Lookout Road Boulder, CO 80301 Attention: General Counsel VIA EMAIL Dear Ms. Blachman: Reference is made to (a) that certain Public Company Support Agreement, dated as of October 13, 2022, by and among Imara Inc., a Delaware corporation (“Imara”), Enliven Therapeutics, Inc., a Delaware corporation ( “Merger Partner”), and Michael Gray,

February 10, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39247 IMARA INC. (Exa

February 8, 2023 SC 13G/A

IMRA / Imara Inc / BML Investment Partners, L.P. - NONE Passive Investment

SC 13G/A 1 doc1.htm NONE UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* IMARA INC (Name of Issuer) Common stock, par value $0.001 per share (Title of Class of Securities) 45249V107 (CUSIP Number) Calendar Year 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to d

January 23, 2023 424B3

PROPOSED MERGER YOUR VOTE IS VERY IMPORTANT

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-268300 PROPOSED MERGER YOUR VOTE IS VERY IMPORTANT To the Stockholders of Imara Inc. and Enliven Therapeutics, Inc., Imara Inc., a Delaware corporation, or Imara, and Enliven Therapeutics, Inc., a Delaware corporation, or Enliven, entered into an Agreement and Plan of Merger, or the Merger Agreement, on October 13, 2022, pursu

January 19, 2023 CORRESP

Imara Inc.

Imara Inc. 1309 Beacon Street, Suite 300, Office 341 Brookline, MA 02446 January 19, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Jenn Do Kevin Vaughn Lauren Hamill Tim Buchmiller Re: Imara Inc. Registration Statement on Form S-4 File No. 333-268300 Request for Acceleration Ladies and Gentlemen: Pursuant to R

January 9, 2023 S-4/A

As filed with the Securities and Exchange Commission on January 6, 2023

S-4/A Table of Contents As filed with the Securities and Exchange Commission on January 6, 2023 Registration No.

January 9, 2023 EX-99.1

Form of Preliminary Proxy Card of Imara Inc.

EX-99.1 Exhibit 99.1 YOUR VOTE IS IMPORTANT! PLEASE VOTE BY: INTERNET Go To: www.proxypush.com/IMRA Cast your vote online Have your Proxy Card ready Follow the simple instructions to record your vote PHONE Call 1-866-829-5506 Use any touch-tone telephone Have your Proxy Card ready Follow the simple recorded instructions MAIL Mark, sign and date your Proxy Card Fold and return your Proxy Card in th

January 9, 2023 EX-10.5

Consulting Agreement between Richard Heyman and Former Enliven

[###] Certain exhibits or schedules to this exhibit have been omitted in compliance with Regulation S-K Item 601(a)(5).

January 6, 2023 CORRESP

Wilmer Cutler Pickering Hale and Dorr LLP, 60 State Street, Boston, Massachusetts 02109 Beijing Berlin Boston Brussels Denver Frankfurt London Los Angeles New York Palo Alto San Francisco Washington

January 6, 2023 +1 617 526 6000 (t) +1 617 526 5000 (f) wilmerhale.com By Electronic Submission Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Jenn Do Kevin Vaughn Lauren Hamill Tim Buchmiller Re: Imara Inc. Amendment No. 1 to Registration Statement on Form S-4 Filed December 19, 2022 File No. 333-268300 Ladies and Gentlemen: O

December 19, 2022 S-4/A

As filed with the Securities and Exchange Commission on December 19, 2022

Table of Contents As filed with the Securities and Exchange Commission on December 19, 2022 Registration No.

December 19, 2022 CORRESP

Wilmer Cutler Pickering Hale and Dorr LLP, 60 State Street, Boston, Massachusetts 02109 Beijing Berlin Boston Brussels Denver Frankfurt London Los Angeles New York Palo Alto San Francisco Washington

December 19, 2022 +1 617 526 6000 (t) +1 617 526 5000 (f) wilmerhale.com By Electronic Submission Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Jenn Do Kevin Vaughn Lauren Hamill Tim Buchmiller Re: Imara Inc. Registration Statement on Form S-4 Filed November 10, 2022 File No. 333-268300 Ladies and Gentlemen: On behalf of Imara

December 5, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 28, 2022 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File Numbe

December 5, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 28, 2022 IMARA INC. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 28, 2022 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File Numbe

November 16, 2022 EX-99.1

UNAUDITED PRO FORMA FINANCIAL INFORMATION

EX-99.1 Exhibit 99.1 UNAUDITED PRO FORMA FINANCIAL INFORMATION On November 10, 2022 (the “Closing Date”), IMARA Inc. (the “Company”) completed the previously announced transaction providing for the sale of tovinontrine (IMR-687) and all other assets of the Company related to its PDE9 program (the “Asset Sale”) to Cardurion Pharmaceuticals, Inc. (“Cardurion”) pursuant to the Asset Purchase Agreemen

November 16, 2022 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 IMARA INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 IMARA INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39247 81-1523849 (State or Other Jurisdiction of Incorporation) (Commission File Num

November 10, 2022 EX-99.4

Consent of Jacob Bauer to be named as a director

Exhibit 99.4 Consent to be Named as a Director Nominee In connection with the filing by Imara Inc. (the ?Company?) of the Registration Statement on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named in the Registration Statement and any and all amendme

November 10, 2022 EX-99.2

Consent of Samuel Kintz to be named as a director

Exhibit 99.2 Consent to be Named as a Director Nominee In connection with the filing by Imara Inc. (the ?Company?) of the Registration Statement on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named in the Registration Statement and any and all amendme

November 10, 2022 EX-99.7

Consent of Richard Heyman, Ph.D., to be named as a director

Exhibit 99.7 Consent to be Named as a Director Nominee In connection with the filing by Imara Inc. (the ?Company?) of the Registration Statement on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named in the Registration Statement and any and all amendme

November 10, 2022 EX-99.5

Consent of Mika Derynck, M.D., to be named as a director

EX-99.5 10 d401639dex995.htm EX-99.5 Exhibit 99.5 Consent to be Named as a Director Nominee In connection with the filing by Imara Inc. (the “Company”) of the Registration Statement on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the “Securities Act”), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named in the Registrat

November 10, 2022 EX-99.3

Consent of Joseph Lyssikatos, Ph.D., to be named as a director

Exhibit 99.3 Consent to be Named as a Director Nominee In connection with the filing by Imara Inc. (the ?Company?) of the Registration Statement on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named in the Registration Statement and any and all amendme

November 10, 2022 EX-10.2

Enliven 2019 Equity Incentive Plan, as amended, including forms of agreements thereunder

Exhibit 10.2 ENLIVEN THERAPEUTICS, INC. 2019 EQUITY INCENTIVE PLAN AS AMENDED AUGUST 9, 2022 1. Purposes of the Plan. The purposes of this Plan are: ? to attract and retain the best available personnel for positions of substantial responsibility, ? to provide additional incentive to Employees, Directors and Consultants, and ? to promote the success of the Company?s business. The Plan permits the g

November 10, 2022 EX-99.6

Consent of Rishi Gupta to be named as a director

Exhibit 99.6 Consent to be Named as a Director Nominee In connection with the filing by Imara Inc. (the ?Company?) of the Registration Statement on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named in the Registration Statement and any and all amendme

November 10, 2022 EX-99.9

Consent of Andrew Schwab to be named as a director

EX-99.9 14 d401639dex999.htm EX-99.9 Exhibit 99.9 Consent to be Named as a Director Nominee In connection with the filing by Imara Inc. (the “Company”) of the Registration Statement on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the “Securities Act”), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named in the Registrat

November 10, 2022 EX-FILING FEES

Filing fee table

EX-FILING FEES 15 d401639dexfilingfees.htm EX-FILING FEES Exhibit 107 Calculation of Filing Fee Table Form S-4 (Form Type) IMARA INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offeri

November 10, 2022 S-4

As filed with the Securities and Exchange Commission on November 10, 2022

Table of Contents As filed with the Securities and Exchange Commission on November 10, 2022 Registration No.

November 10, 2022 EX-99.8

Consent of Andrew Phillips, Ph.D., to be named as a director

Exhibit 99.8 Consent to be Named as a Director Nominee In connection with the filing by Imara Inc. (the ?Company?) of the Registration Statement on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named in the Registration Statement and any and all amendme

November 10, 2022 8-K

Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2022 IMARA INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39247 81-1523849 (State or Other Jurisdiction of Incorporation) (Commission File Number

November 10, 2022 EX-21.1

List of Subsidiaries of Imara Inc.

Exhibit 21.1 List of Subsidiaries Name Jurisdiction of Incorporation IMARA Security Corporation Massachusetts Iguana Merger Sub, Inc. Delaware

October 25, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 IMARA INC.

October 24, 2022 SC 13G

IMRA / Imara Inc / COMMODORE CAPITAL LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

October 24, 2022 SC 13G

IMRA / Imara Inc / RA CAPITAL MANAGEMENT, L.P. - IMARA, INC. Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* IMARA, INC. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 45249V107 (CUSIP Number) October 14, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

October 19, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of

October 14, 2022 EX-99.1

Enliven Therapeutics, Inc. and Imara Inc. Announce Definitive Merger Agreement Transcript of Conference Call Held on October 13, 2022 at 5:00 P.M. Eastern Time

EX-99.1 Exhibit 99.1 Enliven Therapeutics, Inc. and Imara Inc. Announce Definitive Merger Agreement Transcript of Conference Call Held on October 13, 2022 at 5:00 P.M. Eastern Time Operator Good day and welcome to the Enliven Therapeutics/Imara merger announcement conference call. Please note that today’s conference is being recorded for archive purposes. At this time, I’d like to turn the confere

October 14, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 IMARA INC. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File Number

October 14, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 IMARA INC. (Exac

425 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File Nu

October 13, 2022 EX-2.1

Agreement and Plan of Merger, dated as of October 13, 2022, by and among Imara Inc., Iguana Merger Sub, Inc. and Enliven Therapeutics, Inc.

EX-2.1 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER by and among IMARA INC., IGUANA MERGER SUB, INC. and ENLIVEN THERAPEUTICS, INC. Dated as of October 13, 2022 - i - TABLE OF CONTENTS Page ARTICLE I THE MERGER 2 1.1 Effective Time of the Merger 2 1.2 Closing 2 1.3 Effects of the Merger 2 1.4 Directors and Officers of the Surviving Corporation 2 1.5 Public Company Matters 2 ARTICLE II CONVERSION OF SE

October 13, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 IMARA INC. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File Number

October 13, 2022 EX-10.1

Form of Contingent Value Rights Agreement

EX-10.1 Exhibit 10.1 FORM OF CONTINGENT VALUE RIGHTS AGREEMENT BETWEEN IMARA INC. and [ ] Dated as of [•] FORM OF CONTINGENT VALUE RIGHTS AGREEMENT THIS CONTINGENT VALUE RIGHTS AGREEMENT (this “Agreement”), dated as of [•], is entered into by and among Imara Inc. a Delaware corporation (“Public Company”), and [•], as initial Rights Agent (as defined herein). PREAMBLE WHEREAS, Public Company, Iguan

October 13, 2022 EX-99.2

Disclaimer About this Presentation For the purposes of this notice, the “presentation” that follows shall mean and include the slides that follow, the oral presentation of the slides by members of management of Imara Inc. (“Imara”) or Enliven Therape

EX-99.2 Merger Announcement October 13, 2022 Exhibit 99.2 Disclaimer About this Presentation For the purposes of this notice, the “presentation” that follows shall mean and include the slides that follow, the oral presentation of the slides by members of management of Imara Inc. (“Imara”) or Enliven Therapeutics, Inc. (“Enliven”) or any person on their behalf, any question and answer session that

October 13, 2022 EX-10.3

Form of Imara Support Agreement.

EX-10.3 Exhibit 10.3 FORM OF IMARA INC. SUPPORT AGREEMENT This Support Agreement (this “Agreement”) is made and entered into as of [•], 2022, by and among Enliven Therapeutics, Inc. a Delaware corporation (“Merger Partner”), Imara Inc., a Delaware corporation (“Public Company”), and the undersigned stockholder (the “Stockholder”) of Public Company. RECITALS WHEREAS, concurrently with the execution

October 13, 2022 EX-10.4

Form of Lock-Up Agreement

EX-10.4 Exhibit 10.4 FORM OF LOCK-UP AGREEMENT [•], 2022 Imara Inc. Ladies and Gentlemen: The undersigned signatory of this lock-up agreement (this “Lock-Up Agreement”) understands that Imara Inc., a Delaware corporation (“Public Company”), has entered into an Agreement and Plan of Merger, dated as of October 13, 2022 (as the same may be amended from time to time, the “Merger Agreement”) with Igua

October 13, 2022 EX-10.2

Form of Enliven Support Agreement

EX-10.2 Exhibit 10.2 FORM OF ENLIVEN THERAPEUTICS, INC. SUPPORT AGREEMENT This Support Agreement (this “Agreement”) is made and entered into as of [•], 2022, by and among Enliven Therapeutics, Inc., a Delaware corporation (“Merger Partner”), Imara Inc., a Delaware corporation (“Public Company”), and the undersigned stockholder (the “Stockholder”) of Merger Partner. RECITALS WHEREAS, concurrently w

October 13, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 IMARA INC. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 IMARA INC. (Exact name of registrant as specified in its charter) Delaware 001-39247 81-1523849 (State or other jurisdiction of incorporation) (Commission File Number

October 13, 2022 EX-99.1

Enliven Therapeutics and Imara Announce Merger Agreement

EX-99.1 Exhibit 99.1 Enliven Therapeutics and Imara Announce Merger Agreement • Merger to create Nasdaq-listed, clinical-stage biopharmaceutical company focused on advancing Enliven’s portfolio of precision oncology programs • Combined company is expected to have a cash balance of approximately $300 million at close, which is expected to provide cash runway through multiple clinical milestones and

October 7, 2022 DEFM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defi

September 23, 2022 PREM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defi

September 23, 2022 EX-FILING FEES

Calculation of Filing Fee Tables Schedule 14A (Form Type) IMARA INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Transaction Valuation Proposed Maximum Aggregate Value of Transaction (1)(2) Fee rate Amount of Filing Fee Fees to Be

Exhibit 107 Calculation of Filing Fee Tables Schedule 14A (Form Type) IMARA INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Transaction Valuation Proposed Maximum Aggregate Value of Transaction (1)(2) Fee rate Amount of Filing Fee Fees to Be Paid $ 34,750,000 (3) 0.0000927 $ 3,221.33 Fees Previously Paid $ 0 0.0000927 $ 0 Total Transaction Valuation $ 34,750,000 Total Fees Due

September 7, 2022 EX-10.1

Amendment to Retention Agreement, dated as of May 5, 2022, by and between the Registrant and Rahul D. Ballal, Ph.D. (incorporated by reference as Exhibit 10.1 to the Company’s Current Report on Form 8-K filed with the SEC on September 7, 2022).

EXHIBIT 10.1 IMARA Inc. [email protected] www.imaratx.com September 6, 2022 Rahul D. Ballal, Ph.D. Dear Rahul, You are a key member of the senior management team of Imara Inc. (the ?Company?). As a result, the Company would like to amend that certain retention agreement (the ?Retention Agreement?), dated May 5, 2022, pursuant to which you are eligible for certain retention benefits should you remai

September 7, 2022 EX-2.1

Agreement and Plan of Merger, dated as of October 13, 2022, by and among the Registrant, Iguana Merger Sub, Inc. and Enliven Therapeutics, Inc. (incorporated by reference as Exhibit 2.1 to the Company’s Current Report on Form 8-K filed with the SEC on October 13, 2022).

EXHIBIT 2.1 EXECUTION COPY Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential. Double asterisks denote omissions. ASSET PURCHASE AGREEMENT This Asset Purchase Agreement (this ?Agreement?) is made and entered into as of September 6, 2022 (the ?Execution Date?)

September 7, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 6, 2022 IMARA INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39247 81-1523849 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

September 7, 2022 EX-10.2

Amendment to Amended and Restated Retention Agreement, dated as of May 18, 2022, by and between the Registrant and Michael P. Gray (incorporated by reference as Exhibit 10.2 to the Company’s Current Report on Form 8-K filed with the SEC on September 7, 2022).

EXHIBIT 10.2 IMARA Inc. [email protected] www.imaratx.com September 6, 2022 Michael P. Gray Dear Mike, You are a key member of the senior management team of Imara Inc. (the ?Company?). As a result, the Company would like to amend that certain amended and restated retention agreement (the ?Retention Agreement?), dated May 18, 2022, pursuant to which you are eligible for certain retention benefits sh

September 7, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 6, 2022 IMARA INC. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 6, 2022 IMARA INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39247 81-1523849 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

August 3, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 IMARA INC.

August 3, 2022 EX-10.4

Amended and Restated Retention Agreement, dated as of May 18, 2022, by and between the Registrant and Michael P. Gray.

Exhibit 10.4 IMARA Inc. 116 Huntington Avenue, 6th Floor Boston, MA 02116 USA [email protected] +1 617 202-2020 www.imaratx.com May 18, 2022 Michael P. Gray Dear Mike, You are a key member of the senior management team of Imara Inc. (the “Company”). As a result, subject to the terms and conditions of this letter agreement, you will be eligible for the following retention benefits should you remain

July 29, 2022 EX-10.1

Second Amendment and Termination of Office Lease Agreement, effective July 25, 2022, by and between the Registrant and Columbia REIT – 116 Huntington, LLC (incorporated by reference as Exhibit 10.1 to the Company’s Current Report on Form 8-K filed with the SEC on July 29, 2022).

Exhibit 10.1 second aMENDMENT TO, and termination of, office LEASE AGREEMENT THIS SECOND AMENDMENT TO, AND TERMINATION OF, OFFICE LEASE AGREEMENT (this ?Amendment?) is made as of July 21, 2022 (the ?Effective Date?) by and between COLUMBIA REIT ? 116 HUNTINGTON, LLC, a Delaware limited liability company (?Landlord?), and IMARA INC., a Delaware corporation (?Tenant?). RECITALS R.1.Landlord and Tena

July 29, 2022 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 25, 2022 IMARA INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39247 81-1523849 (State or Other Jurisdiction of Incorporation) (Commission File Number) (

June 3, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2022 IMARA INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39247 81-1523849 (State or Other Jurisdiction of Incorporation) (Commission File Number) (I

May 24, 2022 SC 13D/A

IMRA / Imara Inc / New Enterprise Associates 14, L.P. - NEW ENTERPRISE ASSOCIATES 14, L.P. -- IMARA INC. 13DA3E Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* IMARA Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 45249V107 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842-4000 (Name, Address and Tel

May 6, 2022 EX-10.1

Asset Purchase Agreement, dated September 6, 2022, between the Registrant and Cardurion Pharmaceuticals, Inc. (incorporated by reference as Exhibit 2.1 to the Company’s Current Report on Form 8-K filed with the SEC on September 7, 2022).

Exhibit 10.1 SEPARATION AGREEMENT AND GENERAL RELEASE This Separation Agreement and General Release (the ?Agreement?) is entered into by and between Imara Inc. (referred to throughout this Agreement as ?Employer?) and Kenneth M. Attie, M.D. (?Employee?). The term ?Party? or ?Parties? as used herein shall refer to Employer, Employee, or both, as may be appropriate. The Parties are subject to the te

May 6, 2022 EX-10.4

Retention Agreement, dated as of May 5, 2022, by and between the Registrant and Michael P. Gray

Exhibit 10.4 IMARA Inc. 116 Huntington Avenue, 6th Floor Boston, MA 02116 USA [email protected] +1 617 202-2020 www.imaratx.com May 5, 2022 Michael P. Gray Dear Mike, You are a key member of the senior management team of Imara Inc. (the ?Company?). As a result, subject to the terms and conditions of this letter agreement, you will be eligible for the following retention benefits should you remain e

May 6, 2022 EX-10.2

Amendment Number 3 to Exclusive License Agreement, dated as of April 29, 2022, by and between H. Lundbeck A/S and the Registrant

Exhibit 10.2 Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential. Double asterisks denote omissions Amendment Number 3 to Exclusive License Agreement This Amendment Number 3 (the ?Amendment?), effective as of April 29, 2022 (the ?Amendment Effective Date?), is

May 6, 2022 EX-10.3

Retention Agreement, dated as of May 5, 2022, by and between the Registrant and Rahul D. Ballal, Ph.D. (incorporated by reference as Exhibit 10.3 to the Company’s Quarterly Report on Form 10-Q filed with the SEC on May 6, 2022).

Exhibit 10.3 IMARA Inc. 116 Huntington Avenue, 6th Floor Boston, MA 02116 USA [email protected] +1 617 202-2020 www.imaratx.com May 5, 2022 Rahul D. Ballal, Ph.D. Dear Rahul, You are a key member of the senior management team of Imara Inc. (the ?Company?). As a result, subject to the terms and conditions of this letter agreement, you will be eligible for the following retention benefits should you

May 6, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39247 IMARA INC.

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