POAI / Predictive Oncology Inc. - SEC फाइलिंग, वार्षिक रिपोर्ट, प्रॉक्सी स्टेटमेंट

प्रिडिक्टिव ऑन्कोलॉजी इंक.
US ˙ NasdaqCM ˙ US74039M3097

मूलभूत आँकड़े
LEI 549300UQE748N2H9LE74
CIK 1446159
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Predictive Oncology Inc.
SEC Filings (Chronological Order)
यह पृष्ठ SEC फाइलिंग की एक पूरी, कालानुक्रमिक सूची प्रदान करता है, ओनरशिप फाइलिंग को छोड़कर, जो हम अन्यत्र प्रदान करते हैं।
September 2, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 26, 2025 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 26, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organiza

August 18, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(

August 14, 2025 EX-99.1

Predictive Oncology Reports Second Quarter 2025 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Predictive Oncology Reports Second Quarter 2025 Financial Results and Provides Corporate Update PITTSBURGH, Aug. 14, 2025 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tumor samples, and CLIA laboratory to accelerate oncologic drug discover

August 14, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive

August 7, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6

July 29, 2025 424B3

Up to 1,921,706 Shares of Common Stock

Filed pursuant to Rule 424(b)(3) Registration No. 333-288782 PROSPECTUS Up to 1,921,706 Shares of Common Stock This prospectus relates to the resale from time to time by YA II PN, LTD., a Cayman Islands exempt limited company (“Yorkville” or the “Selling Stockholder”) of up to 1,921,706 shares of our Common Stock, par value $0.01 per share (“Common Stock”). The shares of Common Stock to which this

July 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 23, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 23, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizati

July 24, 2025 CORRESP

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 July 24, 2025 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Margaret Sawicki Re: Predictive Oncology Inc. Acceleration Request for Registration Statement on Form S-1 File No. 333-288782 Requested Date: July 28, 2025 Requested Time

July 18, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-1 (Form Type) Predictive Oncology Inc.

July 18, 2025 EX-99.1

EXPLANATORY NOTE

Exhibit 99.1 EXPLANATORY NOTE Predictive Oncology is revising and recasting certain financial and other information included in its 2024 Form 10-K. The relevant information in the 2024 Form 10-K is being updated to retrospectively reflect the results of the Eagan Business as discontinued operations as a result of meeting the criteria for discontinued operations during the three months ended March

July 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizati

July 18, 2025 S-1

As Filed with the Securities and Exchange Commission on July 18, 2025

As Filed with the Securities and Exchange Commission on July 18, 2025 Registration No.

July 11, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 8, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizatio

July 8, 2025 EX-10.1

Standby Equity Purchase Agreement, dated as of July 1, 2025, by and between the Registrant and YA II PN, Ltd.

Exhibit 10.1 STANDBY EQUITY PURCHASE AGREEMENT THIS STANDBY EQUITY PURCHASE AGREEMENT (this “Agreement”) dated as of July 1, 2025 is made by and between YA II PN, LTD., a Cayman Islands exempt limited company (the “Investor”), and PREDICTIVE ONCOLOGY INC., a company incorporated under the laws of the State of Delaware (the “Company”). The Investor and the Company may be referred to herein individu

July 8, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 1, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 1, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizatio

June 11, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

June 6, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

June 2, 2025 424B5

Up to $3,398,000 Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-279123 PROSPECTUS SUPPLEMENT To Prospectus Supplement dated April 18, 2025 (To Prospectus and Prospectus Supplement dated May 21, 2024) Up to $3,398,000 Common Stock This prospectus supplement (the “Prospectus Supplement”) amends and supplements certain information in the prospectus supplement, dated April 18, 2025, to the prospectus, dated

May 15, 2025 EX-99.1

Predictive Oncology Reports First Quarter 2025 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Predictive Oncology Reports First Quarter 2025 Financial Results and Provides Corporate Update PITTSBURGH, May 15, 2025 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tumor samples, and CLIA laboratory to accelerate oncologic drug discovery

May 15, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictiv

April 18, 2025 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2025 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organiza

April 18, 2025 424B5

Up to $1,491,000 Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-279123 PROSPECTUS SUPPLEMENT (To Prospectus and Prospectus Supplement dated May 21, 2024) Up to $1,491,000 Common Stock This prospectus supplement (the “Prospectus Supplement”) amends and supplements certain information in the prospectus, dated May 21, 2024, filed with the Securities and Exchange Commission as part of our registration statem

April 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizati

April 1, 2025 EX-99.1

Predictive Oncology Reports Year-End 2024 Financial Results and Provides Corporate Update Company continues to progress toward the signing of a definitive merger agreement with Renovaro

EXHIBIT 99.1 Predictive Oncology Reports Year-End 2024 Financial Results and Provides Corporate Update Company continues to progress toward the signing of a definitive merger agreement with Renovaro PITTSBURGH, April 01, 2025 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensiv

April 1, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

April 1, 2025 EX-99.1

Predictive Oncology Inc. 2024 Equity Incentive Plan

Exhibit 99.1 PREDICTIVE ONCOLOGY INC. 2024 EQUITY INCENTIVE PLAN 1. Purpose. The purpose of the 2024 Equity Incentive Plan (the “Plan”) of Predictive Oncology Inc. (the “Company”) is to increase shareholder value and to advance the interests of the Company by furnishing a variety of economic incentives (“Incentives”) designed to attract, retain and motivate employees, certain key consultants and d

April 1, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Predictive Oncology Inc.

April 1, 2025 S-8

As Filed with the Securities and Exchange Commission on March 31, 2025

As Filed with the Securities and Exchange Commission on March 31, 2025 Registration No.

March 31, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36790 Predictive Oncology Inc.

March 31, 2025 EX-21.1

List of Subsidiaries. (Filed on March 31, 2025 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference).

Exhibit 21.1 PREDICTIVE ONCOLOGY INC. SUBSIDIARIES OF THE REGISTRANT Subsidiary Jurisdiction of Incorporation Helomics Corporation Delaware Skyline Medical, Inc. Delaware

March 31, 2025 EX-19

Insider Trading Policy

Exhibit 19 PREDICTIVE ONCOLOGY INC. POLICY ON AVOIDANCE OF INSIDER TRADING The Board of Directors of Predictive Oncology Inc., a Delaware corporation (the “Company”), has adopted this Insider Trading Policy for our directors, employees (including officers) and consultants with respect to the trading of the Company’s securities, as well as the securities of publicly traded companies with whom we ha

March 31, 2025 EX-4.7

Exhibit 4.7

Exhibit 4.7 Description of Registrant’s Securities Predictive Oncology Inc. (the “Company”) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), namely, our common stock, par value $0.01 per share (“Common Stock”). Description of Common Stock The following description of our Common Stock is a summary and does not purport t

March 20, 2025 EX-99.1

Predictive Oncology Completes Sale of Skyline Medical Assets to DeRoyal Industries Deal positions STREAMWAY® Systems with an established market leader to drive accelerating growth Transaction allows Predictive Oncology to be highly focused on its cor

EXHIBIT 99.1 Predictive Oncology Completes Sale of Skyline Medical Assets to DeRoyal Industries Deal positions STREAMWAY® Systems with an established market leader to drive accelerating growth Transaction allows Predictive Oncology to be highly focused on its core AI-driven drug discovery capabilities and integrate seamlessly with Renovaro Biosciences PITTSBURGH, March 20, 2025 (GLOBE NEWSWIRE) -

March 20, 2025 EX-10.1

Asset Purchase Agreement, dated March 14, 2025, by and between Predictive Oncology Inc. and DeRoyal Industries, Inc.

Exhibit 10.1 ASSET PURCHASE AGREEMENT This Asset Purchase Agreement (this “Agreement”) dated as of March 14, 2025 is entered into between Predictive Oncology Inc., a Delaware corporation (“Seller”), and DeRoyal Industries, Inc., a Tennessee corporation (“Buyer”). Capitalized terms used in this Agreement have the meanings given to such terms herein. RECITALS WHEREAS, in addition to its other busine

March 20, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2025 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 5, 2025 EX-10.1

Extension Amendment, dated February 28, 2025, by and between Predictive Oncology Inc. and Renovaro, Inc.

Exhibit 10.1 EXTENSION AGREEMENT This Extension Agreement (“Agreement”) is entered into this 28th day of February 2025, by Predictive Oncology, Inc., a Delaware corporation (the “POI”), and Renovaro, Inc. a Delaware corporation (the, “Renovaro”)(collectively, POI and Renovaro may be referred to as the “Parties”). BACKGROUND WHEREAS, POI and Renovaro entered into a definitive Letter agreement dated

March 5, 2025 EX-99.1

Predictive Oncology Moves to Finalize Definitive Merger Agreement With Renovaro Biosciences Predictive receives first tranche of financing to initiate integration of AI/ML platform technologies, core laboratory capabilities and business development e

EXHIBIT 99.1 Predictive Oncology Moves to Finalize Definitive Merger Agreement With Renovaro Biosciences Predictive receives first tranche of financing to initiate integration of AI/ML platform technologies, core laboratory capabilities and business development efforts in Europe and the United States Renovaro’s recent strategic acquisition of BioSymetrics vastly expands Predictive Oncology’s bioma

March 5, 2025 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2025 Predictive Onco

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation)

March 5, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

March 5, 2025 EX-99.1

Predictive Oncology Moves to Finalize Definitive Merger Agreement With Renovaro Biosciences Predictive receives first tranche of financing to initiate integration of AI/ML platform technologies, core laboratory capabilities and business development e

EXHIBIT 99.1 Predictive Oncology Moves to Finalize Definitive Merger Agreement With Renovaro Biosciences Predictive receives first tranche of financing to initiate integration of AI/ML platform technologies, core laboratory capabilities and business development efforts in Europe and the United States Renovaro’s recent strategic acquisition of BioSymetrics vastly expands Predictive Oncology’s bioma

March 5, 2025 EX-10.1

Extension Amendment, dated February 28, 2025, by and between Predictive Oncology Inc. and Renovaro, Inc.

Exhibit 10.1 EXTENSION AGREEMENT This Extension Agreement (“Agreement”) is entered into this 28th day of February 2025, by Predictive Oncology, Inc., a Delaware corporation (the “POI”), and Renovaro, Inc. a Delaware corporation (the, “Renovaro”)(collectively, POI and Renovaro may be referred to as the “Parties”). BACKGROUND WHEREAS, POI and Renovaro entered into a definitive Letter agreement dated

February 19, 2025 424B5

PREDICTIVE ONCOLOGY INC. 363,336 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) File No. 333-279123 PREDICTIVE ONCOLOGY INC. 363,336 Shares of Common Stock We are offering 363,336 shares of our common stock, par value $0.01 per share, pursuant to this prospectus supplement and the accompanying prospectus, directly to institutional investors. Our common stock is listed on The Nasdaq Capital Market under the symbol “POAI.”

February 19, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2025 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

February 19, 2025 EX-99.1

Predictive Oncology Announces Registered Direct Offering Priced At-The-Market Under Nasdaq Rules

EXHIBIT 99.1 Predictive Oncology Announces Registered Direct Offering Priced At-The-Market Under Nasdaq Rules PITTSBURGH, Feb. 19, 2025 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (“Predictive Oncology” or the “Company”), a leader in AI-driven drug discovery and biologics, today announced that it has entered into definitive agreements for the purchase and sale of 363,336 shares of c

February 19, 2025 EX-4.2

Form of Placement Agent Warrant

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

February 19, 2025 EX-10.1

Form of Securities Purchase Agreement dated February 18, 2025

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of February 18, 2025, between Predictive Oncology Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condit

February 19, 2025 EX-99.2

Predictive Oncology Closes Registered Direct Offering

EXHIBIT 99.2 Predictive Oncology Closes Registered Direct Offering PITTSBURGH, Feb. 19, 2025 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (“Predictive Oncology” or the “Company”), a leader in AI-driven drug discovery and biologics, today closed its previously announced registered direct offering for the purchase and sale of 363,336 shares of common stock at a purchase price of $1.50

January 13, 2025 424B3

1,983,302 Shares of Common Stock Issuable Upon Exercise of Warrants

Filed pursuant to Rule 424(b)(3) Registration No. 333- 281579 PROSPECTUS 1,983,302 Shares of Common Stock Issuable Upon Exercise of Warrants This prospectus relates to the offer and resale from time to time by the selling stockholders named in this prospectus of up to an aggregate of 1,983,302 shares of our common stock, par value $0.01 per share. These shares consist of (i) 958,117 shares of comm

January 6, 2025 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 30, 2024 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

January 6, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 1, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

January 6, 2025 EX-1.01

Letter of Intent between Predictive Oncology and Renovaro

Exhibit 1.01 January 1, 2025 Raymond Vennare Predictive Oncology Inc. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 Confidential Dear Raymond, Thank you very much for the opportunity to review Predictive Oncology Inc. (referred to as the “Company”, “Predictive”, or the “Seller”). We have enjoyed our discussions with you to date and are excited about your business model and prospects and very enco

January 6, 2025 EX-99.1

Predictive Oncology Announces Agreement to be Acquired by Renovaro - Combination creates immediate scientific synergies by harnessing complementary AI / ML platforms to improve patient outcomes across multiple cancer indications – - Deal terms align

EXHIBIT 99.1 Predictive Oncology Announces Agreement to be Acquired by Renovaro - Combination creates immediate scientific synergies by harnessing complementary AI / ML platforms to improve patient outcomes across multiple cancer indications – - Deal terms align shareholders’ interest, augment business development opportunities and positioning in the capital markets - PITTSBURGH, Jan. 06, 2025 (GL

November 27, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

November 22, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 22, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 13, 2024 EX-99.1

Predictive Oncology Reports Third Quarter 2024 Financial Results and Provides Strategic Update Company initiates process to explore a broad range of strategic alternatives to maximize shareholder value

EXHIBIT 99.1 Predictive Oncology Reports Third Quarter 2024 Financial Results and Provides Strategic Update Company initiates process to explore a broad range of strategic alternatives to maximize shareholder value PITTSBURGH, Nov. 13, 2024 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabil

November 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predi

September 20, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 19, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organ

August 21, 2024 CORRESP

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 August 21, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Ms. Jane Park, Staff Attorney Re: Predictive Oncology Inc. Acceleration Request for Registration Statement on Form S-3, as amended File No. 333-281579 Requested Date: A

August 15, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-3 (Form Type) Predictive Oncology Inc.

August 15, 2024 S-3

As filed with the Securities and Exchange Commission on August 15, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of r

Registration No. 333- As filed with the Securities and Exchange Commission on August 15, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of incorporation or organizat

August 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2024 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 14, 2024 EX-99.1

Predictive Oncology Reports Second Quarter 2024 Financial Results and Provides Business Update Company to host investor call and webcast today, August 14th, at 8:30am EDT

EXHIBIT 99.1 Predictive Oncology Reports Second Quarter 2024 Financial Results and Provides Business Update Company to host investor call and webcast today, August 14th, at 8:30am EDT PITTSBURGH, Aug. 14, 2024 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository

August 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive

July 29, 2024 EX-99.1

Predictive Oncology Announces Exercise of Warrants for $1.26 Million Gross Proceeds

EXHIBIT 99.1 Predictive Oncology Announces Exercise of Warrants for $1.26 Million Gross Proceeds PITTSBURGH, July 26, 2024 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI), a leader in AI-driven drug discovery and biologics, today announced that it has entered into a definitive agreement for the exercise of certain existing warrants to purchase an aggregate of 958,117 shares of its commo

July 29, 2024 EX-4.2

Form of Series B Common Stock Purchase Warrant dated July 26, 2024 (Filed on July 29, 2024 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

EdgarFiling EXHIBIT 4.2   NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFF

July 29, 2024 EX-4.1

Form of Series A Common Stock Purchase Warrant dated July 26, 2024 (Filed on July 29, 2024 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

EXHIBIT 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

July 29, 2024 EX-4.3

Form of Placement Agent Warrant

EdgarFiling EXHIBIT 4.3   NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFF

July 29, 2024 EX-4.4

Form of Warrant Inducement Agreement

EdgarFiling EXHIBIT 4.4 Predictive Oncology Inc. July 25, 2024 Holder of Common Stock Purchase Warrants Re: Inducement Offer to Exercise Common Stock Purchase Warrants Dear Holder: Predictive Oncology Inc. (the “Company”) is pleased to offer to you (“Holder”, “you” or similar terminology) (i) the opportunity to receive new warrants to purchase shares of the Company’s common stock, par value $0.000

July 29, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 25, 2024 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 25, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

May 30, 2024 EX-99.1

Predictive Oncology Announces Positive Results from Ovarian Cancer Study with UPMC Magee-Womens Hospital to be Presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting Study successfully demonstrated Predictive’s ability to b

EXHIBIT 99.1 Predictive Oncology Announces Positive Results from Ovarian Cancer Study with UPMC Magee-Womens Hospital to be Presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting Study successfully demonstrated Predictive’s ability to build AI multi-omic machine learning models to predict survival outcomes among ovarian cancer patients better than clinical data alone PIT

May 30, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 21, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-3 (Form Type) Predictive Oncology Inc.

May 21, 2024 S-3/A

As filed with the Securities and Exchange Commission on May 21, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc.

Registration No. 333-279123 As filed with the Securities and Exchange Commission on May 21, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of inco

May 20, 2024 CORRESP

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 May 20, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Ms. Jane Park, Staff Attorney Re: Predictive Oncology Inc. Acceleration Request for Registration Statement on Form S-3, as amended File No. 333-279123 Requested Date: May

May 15, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2024 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 15, 2024 EX-99.1

Predictive Oncology Reports First Quarter 2024 Financial Results and Provides Business Update Company to host investor call and webcast today, May 15th, at 8:30am EDT

EXHIBIT 99.1 Predictive Oncology Reports First Quarter 2024 Financial Results and Provides Business Update Company to host investor call and webcast today, May 15th, at 8:30am EDT PITTSBURGH, May 15, 2024 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tu

May 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictiv

May 6, 2024 EX-1.2

Sales Agreement, dated as of May 3, 2024, by and between the Registrant and H.C. Wainwright & Co., LLC.

Exhibit 1.2 Execution Version PREDICTIVE ONCOLOGY INC. Common Stock (par value $0.01 per share) ATM Sales Agreement May 3, 2024 H.C. Wainwright & Co., LLC 430 Park Avenue, 3rd Floor New York, NY 10022 Ladies and Gentlemen: Predictive Oncology Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with H.C. Wainwright & Co., LLC (the “Agent”) as follows: 1. Issuance

May 6, 2024 EX-4.43

Form of Indenture

Exhibit 4.43 Predictive Oncology, Inc. INDENTURE Dated as of , 20 [] Trustee TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1 Definitions 1 Section 1.2 Other Definitions 4 Section 1.3 Incorporation by Reference of Trust Indenture Act 5 Section 1.4 Rules of Construction 5 ARTICLE II THE SECURITIES 6 Section 2.1 Issuable in Series 6 Section 2.2 Establishment

May 6, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-3 (Form Type) Predictive Oncology Inc.

May 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 3, 2024 Predictive Oncology I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 3, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organization

May 6, 2024 EX-10.1

Sales Agreement, dated as of May 3, 2024, by and between the Registrant and H.C. Wainwright & Co., LLC.

Exhibit 10.1 Execution Version PREDICTIVE ONCOLOGY INC. Common Stock (par value $0.01 per share) ATM Sales Agreement May 3, 2024 H.C. Wainwright & Co., LLC 430 Park Avenue, 3rd Floor New York, NY 10022 Ladies and Gentlemen: Predictive Oncology Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with H.C. Wainwright & Co., LLC (the “Agent”) as follows: 1. Issuanc

May 6, 2024 S-3

As filed with the Securities and Exchange Commission on May 3, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of regis

Registration No. 333- As filed with the Securities and Exchange Commission on May 3, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of incorporation or organization)

April 8, 2024 EX-16.1

Letter of BDO USA, P.C. to the Securities and Exchange Commission, dated April 8, 2024.

Exhibit 16.1 Tel: 612-367-3000 Fax: 612-367-3001 www.bdo.com 800 Nicollet Mall, Suite 600 Minneapolis, MN 55402 April 8, 2024 Securities and Exchange Commission 100 F Street N.E. Washington, D.C. 20549 We have been furnished with a copy of the response to Item 4.01 of Form 8-K for the event that occurred on April 3, 2024, to be filed by our former client, Predictive Oncology Inc. We agree with the

April 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2024 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2024 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 28, 2024 EX-97

Policy Relating to Recovery of Erroneously Awarded Compensation

Exhibit 97 PREDICTIVE ONCOLOGY INC. POLICY ON RECOUPMENT OF INCENTIVE COMPENSATION Purpose The purpose of this policy is to set forth the procedures established by the Predictive Oncology (the “Company”) Board of Directors (the “Board”) for the recoupment of certain executive compensation in the event of an accounting restatement resulting from material noncompliance with the financial reporting r

March 28, 2024 EX-99.1

Predictive Oncology Reports Year End 2023 Financial Results and Provides Business Update Company to host investor call and webcast on Monday, April 1st, at 8:30am EDT

EXHIBIT 99.1 Predictive Oncology Reports Year End 2023 Financial Results and Provides Business Update Company to host investor call and webcast on Monday, April 1st, at 8:30am EDT PITTSBURGH, March 28, 2024 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of

March 28, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 28, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 28, 2024 EX-21.1

Subsidiaries of the Registrant

Exhibit 21.1 PREDICTIVE ONCOLOGY INC. SUBSIDIARIES OF THE REGISTRANT Subsidiary Jurisdiction of Incorporation Helomics Corporation Delaware Skyline Medical, Inc. Delaware

March 28, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36790 Predictive Oncology Inc.

March 28, 2024 EX-10.9

Separation Agreement and Mutual Release dated effective September 30, 2023, by and between the Company and Bob Myers.

Exhibit 10.9 SEPARATION AGREEMENT AND MUTUAL RELEASE This Separation Agreement and Mutual Release ("Agreement") is made by and between Robert Myers ("Employee") and Predictive Oncology Inc. (the "Company"), each of whom enter into this Agreement intending to be legally bound. 1. Terms of Employment; Separation Date. a. The terms of Employee's employment with the Company are set forth in that certa

March 22, 2024 8-K/A

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commis

February 8, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 2, 2024 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

January 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 28, 2023 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 28, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

December 7, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

December 5, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

November 14, 2023 EX-99.1

Predictive Oncology Reports Third Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, November 14th, at 8:30am EDT

EXHIBIT 99.1 Predictive Oncology Reports Third Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, November 14th, at 8:30am EDT PITTSBURGH, Nov. 14, 2023 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository

November 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2023 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 13, 2023 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology

August 17, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 10, 2023 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology Inc.

August 10, 2023 EX-99.1

Predictive Oncology Reports Second Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, August 10th, at 5:30pm EDT

EXHIBIT 99.1 Predictive Oncology Reports Second Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, August 10th, at 5:30pm EDT PITTSBURGH, Aug. 10, 2023 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository

August 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event Reported): August 10, 2023 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event Reported): August 10, 2023 Predictive Oncology Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 15, 2023 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology Inc

May 15, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 15, 2023 EX-99.1

Predictive Oncology Reports First Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, May 15th, at 5:30pm EDT

EXHIBIT 99.1 Predictive Oncology Reports First Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, May 15th, at 5:30pm EDT EAGAN, Minn., May 15, 2023 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of

May 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2023 Predictive Oncology I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 2, 2023 Predictive Oncology I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 2, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 2, 2023 EX-99.1

Predictive Oncology Appoints Pharma, Biotech and Digital Health Veteran Veena Rao, PhD, MBA, to its Board of Directors

EXHIBIT 99.1 Predictive Oncology Appoints Pharma, Biotech and Digital Health Veteran Veena Rao, PhD, MBA, to its Board of Directors EAGAN, Minn., May 02, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tumor samples, Clinical Laboratory Improvem

April 20, 2023 EX-3.1

Certificate of Amendment to Certificate of Incorporation (Filed on April 20, 2023 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE CERTIFICATE OF INCORPORATION OF PREDICTIVE ONCOLOGY INC. (a Delaware corporation) Pursuant to Section 242 of the Delaware General Corporation Law, the undersigned, being the Chief Financial Officer of Predictive Oncology Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), does hereby certify that the fo

April 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 19, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 19, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

April 20, 2023 EX-99.1

Predictive Oncology Announces Reverse Stock Split Common Stock Will Begin Trading on Split-Adjusted Basis on April 24, 2023

EXHIBIT 99.1 Predictive Oncology Announces Reverse Stock Split Common Stock Will Begin Trading on Split-Adjusted Basis on April 24, 2023 EAGAN, Minn., April 20, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (“Predictive Oncology” or the “Company”), today announced that it is effecting a reverse stock split of its common stock at a ratio of 1 post-split share for every 20 pre-spli

April 18, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

April 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2023 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

April 5, 2023 EX-16.1

Letter of Baker Tilly US, LLP to the Securities and Exchange Commission, dated April 4, 2023 regarding statements included in this Current Report on Form 8-K

Exhibit 16.1 Baker Tilly US, LLP 225 S Sixth St, Ste 2300 Minneapolis, MN 55402-4661 T: +1 (612) 876 4500 F: +1 (612) 238 8900 bakertilly.com April 4, 2023 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Ladies and Gentlemen: We have read Item 4.01 of Form 8-K, dated on or about April 4, 2023, of Predictive Oncology Inc. and agree with the statements contained in the sec

March 29, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

March 21, 2023 EX-21.1

Subsidiaries of the Registrant

Exhibit 21.1 PREDICTIVE ONCOLOGY INC. SUBSIDIARIES OF THE REGISTRANT Subsidiary Jurisdiction of Incorporation Helomics Corporation Delaware Skyline Medical, Inc. Delaware

March 21, 2023 EX-99.1

Predictive Oncology Reports Year End 2022 Financial Results and Provides Business Update

EXHIBIT 99.1 Predictive Oncology Reports Year End 2022 Financial Results and Provides Business Update EAGAN, Minn., March 21, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (Nasdaq: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tumor samples, Clinical Laboratory Improvement Amendments (CLIA) labora

March 21, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2022.

March 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 17, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

March 16, 2023 EX-3.1

Certificate of Designation of Series F Preferred Stock (Filed on March 16, 2023 as an exhibit to the Form 8-A and incorporated herein by reference.)

Exhibit 3.1 PREDICTIVE ONCOLOGY INC. CERTIFICATE OF DESIGNATION OF SERIES F PREFERRED STOCK Pursuant to Section 151 of the General Corporation Law of the State of Delaware Pursuant to Section 151 of the General Corporation Law of the State of Delaware, Predictive Oncology Inc., a corporation organized and existing under the General Corporation Law of the State of Delaware, in accordance with the p

March 16, 2023 8-A12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 Predictive Oncology Inc. (Exact name of regis

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or other jurisdiction of incorporation or organization) (IRS Employer Identification No.

March 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 16, 2023 EX-99.1

Predictive Oncology Announces Distribution of Series F Preferred Stock to Holders of its Common Stock

EXHIBIT 99.1 Predictive Oncology Announces Distribution of Series F Preferred Stock to Holders of its Common Stock EAGAN, Minn., March 16, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (“Predictive Oncology” or the “Company”), today announced that its Board of Directors declared a dividend of one one-thousandth of a share of newly designated Series F Preferred Stock, par value $0

March 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 14, 2023 EX-99.1

Predictive Oncology Engages LifeSci Advisors as Strategic Investor Relations Partner Comprehensive, multi-faceted IR program to focus on raising awareness of Predictive Oncology and its portfolio of unique, proprietary assets capable of accelerating

EXHIBIT 99.1 Predictive Oncology Engages LifeSci Advisors as Strategic Investor Relations Partner Comprehensive, multi-faceted IR program to focus on raising awareness of Predictive Oncology and its portfolio of unique, proprietary assets capable of accelerating oncologic drug discovery and enabling drug development EAGAN, Minn., March 14, 2023 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI)

March 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2023 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

February 28, 2023 EX-10.1

Employment Agreement dated February 23, 2023 by and between Pamela Bush and Predictive Oncology Inc.

Exhibit 10.1 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (“Agreement”) made and entered into on February 23, 2023, to be effective as of February 1, 2023 (the “Effective Date”) by and between Pamela Bush, an individual, residing at 13418 Canopy Creek Drive, Tampa, Florida 33625 (“Employee”), and Predictive Oncology Inc., 2915 Commers Drive, Suite 900, E

February 28, 2023 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Inco

February 3, 2023 EX-99.1

Predictive Oncology Appoints Pamela Bush, Ph.D., MBA, as Chief Business Officer

Exhibit 99.1 Predictive Oncology Appoints Pamela Bush, Ph.D., MBA, as Chief Business Officer EAGAN, Minn., Feb. 03, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) is pleased to announce the appointment of Pamela Bush, Ph.D., MBA, as Chief Business Officer. Dr. Bush will lead all business development, partnering and growth strategies for Predictive Oncology. As a key member of the

February 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2023 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

December 5, 2022 EX-99.1

Predictive Oncology Appoints Leading Biopharma Executive Matthew J. Hawryluk Ph.D. to the Board of Directors

EXHIBIT 99.1 Predictive Oncology Appoints Leading Biopharma Executive Matthew J. Hawryluk Ph.D. to the Board of Directors EAGAN, Minn., Dec. 05, 2022 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) is pleased to announce the appointment of Matthew J. Hawryluk, Ph.D., (www.predictive-oncology.com) to its Board of Directors to help support the company?s strategic initiatives and commercia

December 5, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 29, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

December 2, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2022 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

November 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 10, 2022 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology

November 10, 2022 EX-99.1

Predictive Oncology Reports Third Quarter Financial Results

Exhibit 99.1 Predictive Oncology Reports Third Quarter Financial Results EAGAN, Minn., Nov. 10, 2022 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) today announced the financial results for its third quarter ended September 30, 2022, which continue to reflect revenue growth and increased gross profit margin as compared to prior year periods. Highlights from the quarter include: Raymond

November 10, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

October 25, 2022 EX-99.1

David S. Smith appointed to the Board of Directors of Predictive Oncology Leading authority on the therapeutic use of human tissues and cells

Exhibit 99.1 David S. Smith appointed to the Board of Directors of Predictive Oncology Leading authority on the therapeutic use of human tissues and cells EAGAN, Minn., Oct. 25, 2022 (GLOBE NEWSWIRE) – Predictive Oncology (NASDAQ: POAI) is pleased to announce the appointment of David S. Smith, JD, to the company’s Board of Directors. Mr. Smith is a life sciences and corporate attorney, veteran bio

October 25, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 19, 2022 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 19, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

October 20, 2022 EX-10.2

Employment Agreement dated effective November 1, 2022, by and between the Company and Raymond F. Vennare. (Filed on October 20, 2022 as an exhibit to our Current Report on Form 8-K).

Exhibit 10.2 EMPLOYMENT AGREEMENT This Employment Agreement (?Agreement?) made and entered into effective as of the 1st day of November 2022 (the ?Effective Date?) by and between Raymond F. Vennare, an individual, residing at 179 West Hutchinson Avenue, Pittsburgh, PA 15218, and Predictive Oncology Inc., 2915 Commers Drive, Suite 900, Eagan, Minnesota 55121, a Delaware corporation (?Company?), col

October 20, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report: September 22, 2022 Predictive Oncology Inc. (Exact name of Registra

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report: September 22, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Number) (IRS Employer Id

October 20, 2022 EX-10.1

Employment Offer Letter dated September 30, 2022, by and between the Company and Raymond F. Vennare. (Filed on September 22, 2022 as an exhibit to our Current Report on Form 8-K).

EX-10.1 2 exh101.htm EXHIBIT 10.1 Exhibit 10.1 September 30, 2022 Raymond Vennare 179 West Hutchinson Avenue Pittsburgh, PA 1528-1321 Dear Raymond: On behalf of Predictive Oncology Inc. (the “Company”), I am very pleased to offer you the position of Chief Executive Officer of Predictive Oncology Inc. This letter establishes the terms of your employment with the Company if you accept this offer. Yo

October 20, 2022 EX-99.1

Predictive Oncology Announces New Chief Executive Officer Raymond F. Vennare to Lead Company Growth

EXHIBIT 99.1 Predictive Oncology Announces New Chief Executive Officer Raymond F. Vennare to Lead Company Growth EAGAN, Minn., Oct. 20, 2022 (GLOBE NEWSWIRE) - Predictive Oncology (NASDAQ: POAI) is pleased to announce the appointment of Raymond F. Vennare as Chief Executive Officer and Chairman of the Board, effective Nov. 1. As an active member on the POAI Board of Directors since September 2021

October 18, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

October 18, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

October 13, 2022 424B3

PREDICTIVE ONCOLOGY INC. 4,737,280 Shares Common Stock

Filed pursuant to 424(b)(3) Registration No. 333-267689 PROSPECTUS PREDICTIVE ONCOLOGY INC. 4,737,280 Shares Common Stock This prospectus relates to the offer and resale from time to time by the selling stockholders named in this prospectus of up to an aggregate of 4,737,280 shares of our common stock, par value $0.01 per share. These shares consist of (i) 3,837,280 shares of common stock issuable

October 11, 2022 CORRESP

Predictive Oncology, Inc. 2915 Commers Drive, Suite 900 Eagan, MN 55121

CORRESP 1 filename1.htm Predictive Oncology, Inc. 2915 Commers Drive, Suite 900 Eagan, MN 55121 October 11, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Benjamin Richie Re: Predictive Oncology, Inc. Registration Statement on Form S-1 File No. 333-267689 Ladies and Gentlemen: Pursuant to Rule 461 u

September 30, 2022 EX-3.10

Second Amended and Restated Bylaws of the Company, effective as of September 9, 2022 (Filed on September 30, 2022 as an exhibit to our Registration Statement on Form S-1 (File No. 333-267689).

Exhibit 3.10 SECOND Amended and Restated BYLAWS of PREDICTIVE ONCOLOGY INC. Effective as of September 9, 2022 ARTICLE 1. OFFICES Section 1.01. Registered Office. The registered office of the Corporation shall be in the City of Wilmington, County of New Castle, State of Delaware. Section 1.02. Other Offices. The Corporation may also have offices at such other places both within and without the Stat

September 30, 2022 S-1

As filed with the Securities and Exchange Commission on September 30, 2022 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name o

S-1 1 fs1093022.htm FORM S-1 Registration No. 333- As filed with the Securities and Exchange Commission on September 30, 2022 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 3842 33-1007393 (State or jurisdiction (Primary

September 30, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables S-1 (Form Type) Predictive Oncology Inc.

September 16, 2022 EX-10.1

Exhibit 10.2

Exhibit 10.1 TRANSITION AND SEPARATION AGREEMENT This Transition and Separation Agreement (?Agreement?) is made and entered into effective as of September 15, 2022, by and between J. Melville Engle (?Employee?) and Predictive Oncology Inc., a Delaware corporation (?the Company?), each of whom enter into this Agreement intending to be legally bound. RECITALS The Company and Employee agree upon the

September 16, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 15, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commis

September 16, 2022 EX-99.1

Predictive Oncology Announces CEO Retirement

EXHIBIT 99.1 Predictive Oncology Announces CEO Retirement EAGAN, Minn., Sept. 16, 2022 (GLOBE NEWSWIRE) - Predictive Oncology (NASDAQ: POAI) today announced that J. Melville (?Mel?) Engle will retire as Chief Executive Officer and as Chairman and a member of the company?s Board of Directors. To ensure a smooth transition of his responsibilities, Mr. Engle will continue to serve in his role through

September 14, 2022 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 9, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

September 14, 2022 EX-3.1

Amendment to Second Amended and Restated Bylaws of Predictive Oncology Inc., dated September 9, 2022

Exhibit 3.1 AMENDMENT TO THE SECOND AMENDED AND RESTATED BYLAWS OF PREDICTIVE ONCOLOGY INC. Pursuant to Article 10 of the Certificate of Incorporation, as amended, of Predictive Oncology Inc., a Delaware corporation (the ?Corporation?), Section 6.06 of the Second Amended and Restated Bylaws of the Corporation (the ?Bylaws?), and Section 109 of the General Corporation Law of the State of Delaware,

August 11, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 11, 2022 EX-99.1

Predictive Oncology Reports Second Quarter 2022 Financial Results

EXHIBIT 99.1 Predictive Oncology Reports Second Quarter 2022 Financial Results EAGAN, Minn., Aug. 11, 2022 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) today announced the financial results for its second quarter ended June 30, 2022, which shows a strong balance sheet with a solid cash balance, commensurate equity and no debt. Highlights from the quarter include: Commercialization la

August 11, 2022 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology Inc.

July 26, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Costs Associated with Exit or Disposal Activities, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 20, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

July 26, 2022 EX-99.1

Predictive Oncology Strengthens Business with Appointment of a Chief Scientific Officer and Consolidation and Expansion of its Research and Development Arm

EXHIBIT 99.1 Predictive Oncology Strengthens Business with Appointment of a Chief Scientific Officer and Consolidation and Expansion of its Research and Development Arm EAGAN, Minn., July 26, 2022 (GLOBE NEWSWIRE) - Predictive Oncology (NASDAQ: POAI) today announced a strategic move to further strengthen its business and product offerings by appointing Julia Kirshner, Ph.D., as Chief Scientific Of

July 26, 2022 EX-10.1

Amended and Restated Employment Agreement, effective as of August 1, 2022, by and between Julia Kirshner and Predictive Oncology Inc.

Exhibit 10.1 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement ("Agreement") made and entered into effective as of August 1 , 2022 (the "Effective Date") by and between Julia Kirshner, an individual, residing at 1625 Meadowlark Lane, Sunnyvale, CA 94087 ("Employee"), and Predictive Oncology Inc . , 2915 Commers Drive, Suite 900 , Eagan, Minnesota 55121 , a De

May 25, 2022 424B3

PREDICTIVE ONCOLOGY INC. 16,671,747 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-254309 PROSPECTUS SUPPLEMENT (To Prospectus Dated March 23, 2021) PREDICTIVE ONCOLOGY INC. 16,671,747 Shares of Common Stock This prospectus supplement (?Supplement?) modifies, supersedes and supplements certain information contained in, and should be read in conjunction with, that certain prospectus (the ?Prospectus?) filed with the Securities

May 25, 2022 424B3

PREDICTIVE ONCOLOGY INC. 5,661,128 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-252584 PROSPECTUS SUPPLEMENT (To Prospectus Dated February 9, 2021) PREDICTIVE ONCOLOGY INC. 5,661,128 Shares of Common Stock This prospectus supplement (?Supplement?) modifies, supersedes and supplements certain information contained in, and should be read in conjunction with, that certain prospectus (the ?Prospectus?) filed with the Securitie

May 25, 2022 424B3

PREDICTIVE ONCOLOGY INC. 15,520,911 Shares of Common Stock Warrants to Purchase up to 15,520,911 Shares of Common Stock Placement Agent Warrants to Purchase up to 1,164,068 Shares of Common Stock (and the shares of Common Stock underlying such Warran

Filed Pursuant to Rule 424(b)(3) Registration No. 333-255582 PROSPECTUS SUPPLEMENT (To Prospectus Supplement June 14, 2021) PREDICTIVE ONCOLOGY INC. 15,520,911 Shares of Common Stock Warrants to Purchase up to 15,520,911 Shares of Common Stock Placement Agent Warrants to Purchase up to 1,164,068 Shares of Common Stock (and the shares of Common Stock underlying such Warrants and Placement Agent War

May 25, 2022 424B3

PREDICTIVE ONCOLOGY INC. 1,396,826 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-239851 PROSPECTUS SUPPLEMENT (To Prospectus Dated July 21, 2020) PREDICTIVE ONCOLOGY INC. 1,396,826 Shares of Common Stock This prospectus supplement (?Supplement?) modifies, supersedes and supplements certain information contained in, and should be read in conjunction with, that certain prospectus (the ?Prospectus?) filed with the Securities a

May 23, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 20, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 18, 2022 424B5

PREDICTIVE ONCOLOGY INC. 3,837,280 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To Prospectus dated May 5, 2021) File No.

May 18, 2022 EX-4.1

Exhibit 4.27

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

May 18, 2022 EX-4.3

Exhibit 4.29

Exhibit 4.3 May 16, 2022 Holder of Warrants to Purchase Common Stock issued on [] Re: Amendment to Existing Warrants Dear Holder: Reference is hereby made to the offering on or about the date hereof (the ?Offering?) by Predictive Oncology Inc. (the ?Company?) of shares of its common stock, par value $0.01 per share (?Common Stock?) (collectively, the ?Shares?). This letter confirms that, in consid

May 18, 2022 EX-10.1

Exhibit 10.25

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of May 16, 2022, between Predictive Oncology Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively the ?Purchasers?). WHEREAS, subject to the terms and conditions

May 18, 2022 424B5

PREDICTIVE ONCOLOGY INC. 8,162,720 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To Prospectus dated May 5, 2021) File No.

May 18, 2022 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 18, 2022 EX-1.1

Engagement Letter with H.C. Wainwright & Co., dated May 9, 2022

Exhibit 1.1 Execution Version May 9, 2022 STRICTLY CONFIDENTIAL Predictive Oncology Inc. 2915 Commers Drive, Suite 900 Eagan, Minnesota 55121 Attn: J. Melville Engle, Chief Executive Officer Dear Mr. Engle: This letter agreement (this ?Agreement?) constitutes the agreement between Predictive Oncology Inc. (the ?Company?) and H.C. Wainwright & Co., LLC (?Wainwright?), that Wainwright shall serve as

May 18, 2022 EX-10.2

Exhibit 10.26

Exhibit 10.2 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of May 16, 2022, between Predictive Oncology Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively the ?Purchasers?). WHEREAS, subject to the terms and conditions

May 18, 2022 EX-99.1

Predictive Oncology Announces $7.2 Million Registered Direct Offerings

EXHIBIT 99.1 Predictive Oncology Announces $7.2 Million Registered Direct Offerings EAGAN, Minn., May 16, 2022 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (Nasdaq: POAI) (?Predictive Oncology? or ?the Company?), a knowledge-driven company focused on applying artificial intelligence (?AI?) to personalized medicine and drug discovery, today announced that it has entered into definitive agreements wi

May 18, 2022 EX-4.2

Form of Placement Agent Warrant

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

May 13, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 12, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 12, 2022 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology Inc

May 12, 2022 EX-99.1

Predictive Oncology Reports First Quarter Financial Results

EXHIBIT 99.1 Predictive Oncology Reports First Quarter Financial Results EAGAN, Minn., May 12, 2022 (GLOBE NEWSWIRE) - The financial results from the first quarter we believe depicts a solid potential for growth in the upcoming period, in accordance with the report by Predictive Oncology Inc. (NASDAQ: POAI) today, disclosing the results for the quarter ended March 31, 2022. The consolidated result

March 31, 2022 EX-99.1

Predictive Oncology Reports Year End 2021 Financial Results and Provides Business Update

EXHIBIT 99.1 Predictive Oncology Reports Year End 2021 Financial Results and Provides Business Update EAGAN, Minn., March 31, 2022 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a knowledge-driven company focused on applying artificial intelligence (?AI?) to personalized medicine and drug discovery, today reported financial results for the year ended December 31, 2021, a period defined by

March 31, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 31, 2022 EX-10.5

Form of Stock Option Agreement for Employees under Amended and Restated 2012 Stock Incentive Plan (Filed on March 31, 2022 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference).

Exhibit 10.5 PREDICTIVE ONCOLOGY INC. STOCK OPTION AGREEMENT (Employee) This STOCK OPTION AGREEMENT (the ?Agreement?) is made and entered into effective as of [?], between Predictive Oncology Inc., a Delaware corporation (the ?Company?) and the undersigned employee (?Employee?). BACKGROUND A. Employee has either been hired to serve as an employee to the Company or the Company desires to induce Emp

March 31, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 31, 2022 EX-4.14

Description of Registrant’s Securities. (Filed on March 31, 2022 as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2021 and incorporated herein by reference.)

Exhibit 4.14 Description of Registrant?s Securities As of March 25, 2022, Predictive Oncology Inc. (the ?Company?) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?), namely, our common stock, par value $0.01 per share (?Common Stock?). Description of Common Stock The following description of our Common Stock is a summary

March 31, 2022 EX-21.1

Exhibit 22.1

Exhibit 21.1 PREDICTIVE ONCOLOGY INC. SUBSIDIARIES OF THE REGISTRANT Subsidiary Jurisdiction of Incorporation Helomics Holding Corporation Delaware TumorGenesis Inc. Delaware Soluble Biotech Inc. Delaware Skyline Medical, Inc. Delaware Helomics Intermediate Corporation Delaware Helomics Corporation Delaware zPredicta, Inc. Delaware

March 31, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2021.

March 31, 2022 EX-10.6

Form of Stock Option Agreement for Executive Officers under Amended and Restated 2012 Stock Incentive Plan (Filed on March 31, 2022 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference).

Exhibit 10.6 PREDICTIVE ONCOLOGY INC. NON-QUALIFIED STOCK OPTION AGREEMENT (Executive) This STOCK OPTION AGREEMENT (the ?Agreement?) is made and entered into effective as of [?] between Predictive Oncology Inc., a Delaware corporation (the ?Company?) and [?] (?Employee?). BACKGROUND A. Employee has either been hired to serve as an employee to the Company or the Company desires to induce Employee t

March 31, 2022 EX-10.7

Form of Stock Option Agreement for Directors under Amended and Restated 2012 Stock Incentive Plan (Filed on March 31, 2022 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference).

Exhibit 10.7 PREDICTIVE ONCOLOGY INC. NON-QUALIFIED STOCK OPTION AGREEMENT (Director) This STOCK OPTION AGREEMENT (the ?Agreement?) is made and entered into effective as of [?], between Predictive Oncology Inc., a Delaware corporation (the ?Company?) and [?]. (?Director?). BACKGROUND A. Director is serving as a member of the board of directors of the Company (the ?Board?) and the Company desires t

February 18, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 17, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

February 11, 2022 SC 13G/A

POAI / Predictive Oncology Inc / INTRACOASTAL CAPITAL, LLC - AMENDMENT NO. 1 TO SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Predictive Oncology Inc. (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Securities) 7403PM200 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

February 10, 2022 EX-99.3

PREDICTIVE ONCOLOGY INC. UNAUDITED PRO FORMA CONDENSED COMBINED BALANCE SHEET AS OF SEPTEMBER 30, 2021

EX-99.3 5 exh993.htm EXHIBIT 99.3 Exhibit 99.3 PREDICTIVE ONCOLOGY INC. UNAUDITED PRO FORMA CONDENSED COMBINED BALANCE SHEET AS OF SEPTEMBER 30, 2021 (Unaudited) Predictive Oncology zPREDICTA Pro Forma Adjustments Note Ref Pro Forma ASSETS Current Assets: Cash and Cash Equivalents $ 41,771,515 $ 440,161 (10,015,941 ) a $ 32,195,735 Accounts Receivable 275,860 76,189 - 351,382 Inventories 397,976 -

February 10, 2022 EX-99.2

zPREDICTA, Inc. BALANCE SHEETS

Exhibit 99.2 zPREDICTA, Inc. BALANCE SHEETS September 30, 2021 December 31, 2020 (unaudited) (audited) ASSETS Current Assets: Cash $ 440,161 $ 170,141 Accounts Receivable 76,189 51,961 Prepaid Expense and Other Assets 31,267 25,630 Total Current Assets 547,617 247,732 Total Assets $ 547,617 $ 247,732 LIABILITIES AND STOCKHOLDERS' DEFICIT Current Liabilities: Accounts Payable $ 2,877 $ 16,199 Accru

February 10, 2022 8-K/A

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 24, 2021 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commi

February 10, 2022 EX-99.1

Independent Auditors' Report

EX-99.1 3 exh991.htm EXHIBIT 99.1 Exhibit 99.1 Independent Auditors' Report To the Stockholders and Board of Directors of zPredicta, Inc. Opinion We have audited the financial statements of zPredicta, Inc. (the Company), which comprise the balance sheets as of December 31, 2020 and 2019, and the related statements of operations, stockholders' equity and cash flows for the years then ended, and the

January 4, 2022 8-K

Submission of Matters to a Vote of Security Holders

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 30, 2021 Predictive Oncology Inc. (Exact name of registrant as specified in charter) Delaware 001-36790 33-1007393 (State or other jurisdiction (Commission (IRS Employer of incorporation)

December 27, 2021 EX-99.1

Predictive Oncology Adjourns Annual Meeting of Stockholders to December 30, 2021

EX-99.1 2 exh991.htm EXHIBIT 99.1 EXHIBIT 99.1 Predictive Oncology Adjourns Annual Meeting of Stockholders to December 30, 2021 MINNEAPOLIS, Dec. 27, 2021 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a knowledge-driven company focused on applying artificial intelligence (“AI”) to personalized medicine and drug discovery, announced today that the Company’s Annual Meeting of Stockholders w

December 27, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 23, 2021 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

December 1, 2021 EX-99.1

Predictive Oncology Acquires zPREDICTA, Inc. zPREDICTA has developed a patented tumor-specific 3D cell culture platform that is complementary to Predictive Oncology’s Artificial Intelligence (AI) platform developed by Helomics. zPREDICTA’s uniquely d

EXHIBIT 99.1 Predictive Oncology Acquires zPREDICTA, Inc. zPREDICTA has developed a patented tumor-specific 3D cell culture platform that is complementary to Predictive Oncology?s Artificial Intelligence (AI) platform developed by Helomics. zPREDICTA?s uniquely designed 3D culture systems create a tumor microenvironment that is closer to the patient?s actual tumor than the currently available alte

December 1, 2021 EX-2.1

Agreement and Plan of Merger dated November 24, 2021 by and among the Company, Golden Gate Acquisition, Inc., zPREDICTA, Inc. and Tom Kelly, as Representative (Filed on December 1, 2021 as an exhibit to our Current Report on Form 8-K, and incorporated herein by reference).

EX-2.1 2 exh21.htm EXHIBIT 2.1 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER by and among zPREDICTA, INC. GOLDEN GATE ACQUISITION INC. PREDICTIVE ONCOLOGY INC. and TOM KELLY, AS COMPANY INTEREST REPRESENTATIVE Dated as of November 24, 2021 AGREEMENT AND PLAN OF MERGER THIS AGREEMENT AND PLAN OF MERGER (this “Agreement”) is made and entered into as of November 24, 2021, by and among Predictive Oncology

December 1, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 24, 2021 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2021 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 10, 2021 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology

November 10, 2021 EX-99.1

Predictive Oncology Reports Third Quarter Financial Results

EXHIBIT 99.1 Predictive Oncology Reports Third Quarter Financial Results EAGAN, Minn., Nov. 10, 2021 (GLOBE NEWSWIRE) - Results from the third quarter show strong potential for future growth, said Predictive Oncology (Nasdaq: POAI) today, announcing financial results for the quarter ended September 30, 2021. All three of Predictive Oncology?s reportable segments recognized revenue for the quarter,

November 5, 2021 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEF 14A 1 def14a110521.htm DEFINITIVE PROXY STATEMENT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as p

September 15, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 13, 2021 Predictive Onc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 13, 2021 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commis

September 15, 2021 EX-99.1

Predictive Oncology Inc. Announces Newest Board Member

EXHIBIT 99.1 Predictive Oncology Inc. Announces Newest Board Member MINNEAPOLIS, Sept. 15, 2021 (GLOBE NEWSWIRE) - Predictive Oncology (NASDAQ: POAI), a knowledge-driven company focused on applying artificial intelligence (?AI?) to personalized medicine and drug discovery, is excited to announce that Raymond F. Vennare was elected to the Board of Directors, pursuant to action of the Board effectiv

September 2, 2021 EX-4.1

Amended and Restated 2012 Stock Incentive Plan (filed herewith)

Exhibit 4.1 PREDICTIVE ONCOLOGY INC. AMENDED AND RESTATED 2012 STOCK INCENTIVE PLAN Effective August 10, 2021* TABLE OF CONTENTS 1. Purpose 3 2. Administration 3 3. Eligible Participants 3 4. Types of Incentives 3 5. Shares Subject to the Plan 4 5.1. Number of Shares 4 5.2. Cancellation 4 5.3. Type of Common Stock 4 5.4. Limitation on Awards Granted to Non-Employee Directors 4 6. Stock Options 4 6

September 2, 2021 S-8

As filed with the Securities and Exchange Commission on September 2, 2021 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 PREDICTIVE ONCOLOGY INC. (Exact name of

Registration No. 333- As filed with the Securities and Exchange Commission on September 2, 2021 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 PREDICTIVE ONCOLOGY INC. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or other jurisdiction of 2915 Commers Drive, Suite 900 Eagan

August 19, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 17, 2021 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 17, 2021 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 19, 2021 EX-99.1

Predictive Oncology Announces Results of Charter Amendment Proposal at Special Meeting

EXHIBIT 99.1 Predictive Oncology Announces Results of Charter Amendment Proposal at Special Meeting MINNEAPOLIS, Aug. 18, 2021 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a knowledge-driven company focused on applying artificial intelligence (?AI?) to personalized medicine and drug discovery, announced today that on August 17, 2021, the stockholders approved an amendment to the Company?

August 19, 2021 EX-3.1

Certificate of Amendment to the Certificate of Incorporation, doubling number of shares of common stock and preferred stock due to stock split. (Filed on August 19, 2021 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE CERTIFICATE OF INCORPORATION OF PREDICTIVE ONCOLOGY INC. (A Delaware Corporation) Pursuant to Section 242 of the Delaware General Corporation Law, the undersigned, being the Chief Financial Officer of Predictive Oncology Inc., a corporation organized and existing under the laws of the State of Delaware (the "Corporation"), does hereby certify that the fo

August 12, 2021 EX-99.1

Predictive Oncology Adjourns Special Meeting of Stockholders

EXHIBIT 99.1 Predictive Oncology Adjourns Special Meeting of Stockholders MINNEAPOLIS, Aug. 11, 2021 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a knowledge-driven company focused on applying artificial intelligence (?AI?) to personalized medicine and drug discovery, announced today that the Company?s Special Meeting of Stockholders, which was convened at 3:00 p.m. Central Time on Augus

August 12, 2021 8-K

Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2021 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 11, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

August 11, 2021 EX-99.1

Predictive Oncology Reports Financial Results for Quarter Ended June 30, 2021, and Provides Business Update

EXHIBIT 99.1 Predictive Oncology Reports Financial Results for Quarter Ended June 30, 2021, and Provides Business Update MINNEAPOLIS, Aug. 11, 2021 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a knowledge-driven company focused on applying artificial intelligence (?AI?) to personalized medicine and drug discovery, today reported financial results for the quarter ended June 30, 2021, and

August 11, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2021 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 11, 2021 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology Inc.

July 20, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

July 7, 2021 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? ? Filed by a Party other than the Registrant ? ? Check the appropriate box: ? Preliminary Proxy Statement ? ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

June 25, 2021 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

June 16, 2021 EX-4.2

Form of Placement Agent Warrant dated June 16, 2021. (Filed on June 16, 2021 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

Exhibit 4.2 Placement Agent COMMON STOCK PURCHASE WARRANT PREDICTIVE ONCOLOGY INC. Warrant Shares: Issue Date: , 2021 THIS Placement Agent COMMON STOCK PURCHASE WARRANT (the ?Warrant?) certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the Authoriz

June 16, 2021 EX-10.1

Exhibit 10.24

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of June 14, 2021, between Predictive Oncology Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively the ?Purchasers?). WHEREAS, subject to the terms and conditions

June 16, 2021 EX-99.1

Predictive Oncology Announces $21.34 Million Registered Direct Offering Priced At-The-Market under Nasdaq Rules

Exhibit 99.1 Predictive Oncology Announces $21.34 Million Registered Direct Offering Priced At-The-Market under Nasdaq Rules June 14, 2021 MINNEAPOLIS, June 14, 2021 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (?Predictive Oncology? or ?the Company?), a knowledge-driven company focused on applying artificial intelligence (?AI?) to personalized medicine and drug discovery, today anno

June 16, 2021 EX-1.2

Amendment to Engagement Letter

Exhibit 1.2 June 15, 2021 STRICTLY CONFIDENTIAL Predictive Oncology Inc. 2915 Commers Drive, Suite 900 Eagan, Minnesota 55121 Attn: J. Melville Engle, Chief Executive Officer Dear Mr. Engle: Reference is made to that certain engagement agreement (the ?Engagement Agreement?), dated as of January 7, 2021, by and between Predictive Oncology Inc. (the ?Company?) and H.C. Wainwright & Co., LLC (?Wainwr

June 16, 2021 EX-4.1

Form of Common Stock Purchase Warrant dated June 16, 2021. (Filed on June 16, 2021 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

Exhibit 4.1 COMMON STOCK PURCHASE WARRANT PREDICTIVE ONCOLOGY INC. Warrant Shares: Issue Date: , 2021 THIS COMMON STOCK PURCHASE WARRANT (the ?Warrant?) certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the Authorized Share Increase Date (the ?Ini

June 16, 2021 424B5

PREDICTIVE ONCOLOGY INC. 15,520,911 Shares of Common Stock Warrants to Purchase up to 15,520,911 Shares of Common Stock Placement Agent Warrants to Purchase up to 1,164,068 Shares of Common Stock (and the shares of Common Stock underlying such Warran

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To Prospectus dated May 5, 2021) File No.

June 16, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2021 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

May 20, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 17, 2021 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 20, 2021 EX-10.1

2021 Long Term Incentive Plan

Exhibit 10.1 Predictive Oncology Inc. (POAI) 2021 Long-Term Incentive Plan (LTIP) Effective May 17, 2021 Goals of Long-Term Incentive Plan Long-Term Incentive Plan (LTIP) awards are intended to reward senior executives in a manner that aligns remuneration with the creation of shareholder wealth. Under the LTIP, the CEO and CFO, are being granted equity awards under the Amended and Restated 2012 St

May 12, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event Reported): May 12, 2021 Predictive Oncology Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File

May 12, 2021 EX-99.1

Predictive Oncology Reports Financial Results for Quarter Ended March 31, 2021 and Provides Business Update

EXHIBIT 99.1 Predictive Oncology Reports Financial Results for Quarter Ended March 31, 2021 and Provides Business Update MINNEAPOLIS, May 12, 2021 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (Nasdaq: POAI), a knowledge-driven company focused on applying artificial intelligence (“AI”) to personalized medicine and drug discovery, today reported financial results for the quarter ended March 31, 2021

May 12, 2021 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology Inc

May 3, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 1, 2021 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 3, 2021 CORRESP

May 3, 2021

May 3, 2021 BY EDGAR United States Securities and Exchange Commission 100 F Street, NE Washington, D.

April 28, 2021 S-3

- FORM S-3

Registration No. 333- As filed with the Securities and Exchange Commission on April 28, 2021 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of incorporation or organizati

April 27, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event Reported): April 21, 2021 Predictive Oncology Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission Fil

April 27, 2021 EX-99.1

Predictive Oncology Inc. Announces Newest Board Member

EXHIBIT 99.1 Predictive Oncology Inc. Announces Newest Board Member MINNEAPOLIS, April 27, 2021 (GLOBE NEWSWIRE) - Predictive Oncology (NASDAQ: POAI), a knowledge-driven company focused on applying artificial intelligence (?AI?) to personalized medicine and drug discovery, is excited to announce today their newest Board Member Dr. Christina Jenkins. Dr. Christina Jenkins is a strategic advisor and

April 7, 2021 EX-10.1

Exhibit 10.22

Exhibit 10.1 EMPLOYMENT AGREEMENT This Employment Agreement (?Agreement?) made and entered into effective as of the 19th day of March 2021 (the ?Effective Date?) by and between J. Melville Engle, an individual, residing at 8778 E. 152nd Place, Thornton, CO 80602 (?Employee?), and Predictive Oncology Inc., 2915 Commers Drive, Suite 900, Eagan, Minnesota 55121, a Delaware corporation (?Company?), co

April 7, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 5, 2021 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 24, 2021 424B3

PREDICTIVE ONCOLOGY INC. 16,671,747 Shares Common Stock

Filed Pursuant to Rule 424(b)(3) File No. 333-254309 PREDICTIVE ONCOLOGY INC. 16,671,747 Shares Common Stock This prospectus relates to the offer and resale of up to 16,671,747 shares of our common stock, par value $0.01 per share, by the selling stockholders as listed in the selling stockholders table on page 15 (the ?Selling Stockholders?). For more information about the Selling Stockholders, pl

March 23, 2021 EX-99.1

Predictive Oncology Inc. Announces New CEO

Exhibit 99.1 Predictive Oncology Inc. Announces New CEO Minneapolis, March 23 2021 - Predictive Oncology (NASDAQ: POAI), a knowledge-driven company focused on applying artificial intelligence to personalized medicine and drug discovery, is excited to announce today that they have appointed J. Melville (“Mel”) Engle as Chief Executive Officer of the company. In addition to being named CEO, Mr. Engl

March 23, 2021 EX-10.3

Exhibit 10.21

Exhibit 10.3 March 19, 2021 Mr. J. Melville Engle 8778 E. 152nd Place Thornton, CO 80602 Dear Mel: On behalf of Predictive Oncology, Inc. (the ?Company?), I am very pleased to offer you the position of Chief Executive Officer of Predictive Oncology, Inc. This letter establishes the terms of your employment with the Company if you accept this offer. You will remain Chairman of the Board unless othe

March 23, 2021 S-3/A

- FORM S-3/A

Registration No. 333-254309 As filed with the Securities and Exchange Commission on March 23, 2021 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of in

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